Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.55 |
| ▸ | PDGFRB known ✓ | P09619 | 1/20 | 0.55 |
| ▸ | TUBB4A known ✓ | P04350 | 4/20 | 0.48 |
| ▸ | TUBB known ✓ | P07437 | 4/20 | 0.48 |
| ▸ | TUBA3C known ✓ | P0DPH7 | 4/20 | 0.48 |
| ▸ | TUBA1B known ✓ | P68363 | 4/20 | 0.48 |
| ▸ | TUBA4A known ✓ | P68366 | 4/20 | 0.48 |
| ▸ | TUBB4B known ✓ | P68371 | 4/20 | 0.48 |
| ▸ | TUBB3 known ✓ | Q13509 | 4/20 | 0.48 |
| ▸ | TUBB2A known ✓ | Q13885 | 4/20 | 0.48 |
| ▸ | TUBB8 known ✓ | Q3ZCM7 | 4/20 | 0.48 |
| ▸ | TUBA3E known ✓ | Q6PEY2 | 4/20 | 0.48 |
| ▸ | TUBA1A known ✓ | Q71U36 | 4/20 | 0.48 |
| ▸ | TUBA1C known ✓ | Q9BQE3 | 4/20 | 0.48 |
| ▸ | TUBB6 known ✓ | Q9BUF5 | 4/20 | 0.48 |
| ▸ | TUBB2B known ✓ | Q9BVA1 | 4/20 | 0.48 |
| ▸ | TUBB1 known ✓ | Q9H4B7 | 4/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1957258 | 1.00 | RECQL (0.55) | RECQLSMN1; SMN2HIF1AEGFRPDGFRB | |
| SCHEMBL1959904 | 0.93 | SMN1; SMN2 (0.62) | RECQLSMN1; SMN2HIF1AEGFRPDGFRB | |
| SCHEMBL1959906 | 0.93 | SMN1; SMN2 (0.62) | RECQLSMN1; SMN2HIF1AEGFRPDGFRB | |
| Hydrochloric Acid SCHEMBL1959671 | 0.91 | SMN1; SMN2 (0.60) | RECQLSMN1; SMN2HIF1AEGFRPDGFRB | |
| Hydrochloric Acid SCHEMBL1959669 | 0.91 | SMN1; SMN2 (0.60) | RECQLSMN1; SMN2HIF1AEGFRPDGFRB | |
| SCHEMBL6904792 | 0.83 | PDE4A (0.55) | RECQLSMN1; SMN2HIF1AEGFRPDGFRB | |
| SCHEMBL6904789 | 0.83 | PDE4A (0.55) | RECQLSMN1; SMN2HIF1AEGFRPDGFRB | |
| SCHEMBL5001733 | 0.80 | MAPT (0.59) | RECQLSMN1; SMN2HIF1AEGFRPDGFRB | |
| SCHEMBL5001730 | 0.80 | MAPT (0.59) | RECQLSMN1; SMN2HIF1AEGFRPDGFRB | |
| SCHEMBL4995254 | 0.80 | TUBB4A (0.58) | RECQLSMN1; SMN2HIF1AEGFRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2332905-B1 | BCRP/ABCG2 Inhibitor | YAKULT HONSHA KK (JP) | 2017-03-01 | — | — | EP | disclosed |
| US-8697742-B2 | BCRP/ABCG2 inhibitor | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2014-04-15 | — | — | US | disclosed |
| EP-2332905-A1 | BCRP/ABCG3 Inhibitor | Kabushiki Kaisha Yakult Honsha (JP) | 2011-06-15 | — | — | EP | disclosed |
| US-20090253656-A1 | BCRP/ABCG2 INHIBITOR | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2009-10-08 | — | — | US | disclosed |
| EP-1864972-A1 | BCRP/ABCG2 INHIBITOR | Kabushiki Kaisha Yakult Honsha (JP) | 2007-12-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253656-A1 | BCRP/ABCG2 INHIBITOR | ABCC1, ABCB1, BRCA1 | EGFR 830/4885PDGFRB 1483/4885TUBB4A 1621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.