SCHEMBL19579263

SCHEMBL19579263

N#Cc1ccc(-c2cc(F)c(F)cc2-c2ccc(C#N)cc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 3/20 0.52
PTGS1 P23219 2/20 0.49
MMP3 P08254 1/20 0.46
GCGR P47871 1/20 0.43
MAPK14 Q16539 1/20 0.43
PDE3B Q13370 1/20 0.42
PDE3A Q14432 1/20 0.42
CYP11B2 P19099 4/20 0.42
AR P10275 1/20 0.41
CA12 O43570 2/20 0.41
CA2 P00918 2/20 0.41
CA9 Q16790 2/20 0.41
ALDH1A1 P00352 1/20 0.41
CYP2A6 P11509 1/20 0.41
CA3 P07451 1/20 0.41
CA6 P23280 1/20 0.41
CA14 Q9ULX7 1/20 0.41
PTGS2 P35354 2/20 0.40
EGLN2 Q96KS0 2/20 0.40
CYP11B1 P15538 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19579048 0.91 KIF11 (0.52) KIF11PTGS1MMP3GCGRMAPK14
SCHEMBL19917526 0.88 KIF11 (0.46) KIF11PTGS1MMP3GCGRMAPK14
SCHEMBL19579265 0.84 KIF11 (0.50) KIF11PTGS1MMP3GCGRMAPK14
SCHEMBL6721732 0.83 CA12 (0.70) PTGS1CA12CA2CA9PTGS2
SCHEMBL19917524 0.82 TRPV4 (0.46) KIF11PTGS1MMP3GCGRMAPK14
SCHEMBL18375385 0.81 MMP3 (0.50) KIF11PTGS1MMP3CYP11B2CA12
SCHEMBL27806612 0.81 KIF11 (0.51) KIF11PTGS1MMP3GCGRMAPK14
SCHEMBL397141 0.81 KIF11 (0.61) KIF11PTGS1MMP3GCGRMAPK14
SCHEMBL19579051 0.79 PTGS1 (0.50) KIF11PTGS1MMP3GCGRMAPK14
SCHEMBL19579102 0.78 PTGS1 (0.50) KIF11PTGS1MMP3GCGRMAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3452471-B1 ORGANIC MOLECULES, ESPECIALLY FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2021-12-08 EP disclosed
WO-2017190885-A1 ORGANIC MOLECULES, ESPECIALLY FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2017-11-09 WO disclosed