Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.39 |
| ▸ | ERN1 | O75460 | 4/20 | 0.39 |
| ▸ | XDH | P47989 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2480246 | 0.90 | XDH (0.43) | CYP26A1ERN1XDHCA12CA9 | |
| SCHEMBL1958177 | 0.81 | XDH (0.49) | ERN1XDHCA12CA9MIF | |
| SCHEMBL387189 | 0.81 | XDH (0.51) | PTGS2PTGS1ERN1XDHMEN1 | |
| SCHEMBL1957905 | 0.80 | PTGS2 (0.42) | PTGS2PTGS1ERN1XDHCA12 | |
| SCHEMBL6001180 | 0.78 | PELI1 (0.47) | ERN1XDHCA12CA9MIF | |
| SCHEMBL5013561 | 0.77 | XDH (0.51) | ERN1XDHMEN1LMNAKMT2A | |
| SCHEMBL289452 | 0.77 | BACE1 (0.49) | ERN1CA9MEN1LMNAMAPT | |
| SCHEMBL31302309 | 0.77 | BACE1 (0.49) | ERN1CA9MEN1LMNAMAPT | |
| SCHEMBL29100201 | 0.76 | TRIM24 (0.42) | CYP26A1ERN1MEN1LMNAMAPT | |
| SCHEMBL869016 | 0.74 | ERN1 (0.47) | ERN1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507229-A1 | SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES | Abbott Laboratories (US) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011068561-A1 | SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | disclosed |