Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.40 |
| ▸ | MLYCD | O95822 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21028343 | 0.88 | LMNA (0.42) | ALDH1A1LMNAHTTCACNA1H | |
| SCHEMBL20877084 | 0.85 | CES2 (0.55) | NOTUMGAACES2ANO1DDR1 | |
| SCHEMBL17789598 | 0.85 | MEN1 (0.44) | POLBLMNAHTTCACNA1H | |
| SCHEMBL19590713 | 0.82 | KMT2A (0.39) | ANO1LMNAHTTCACNA1H | |
| SCHEMBL16142872 | 0.81 | NOTUM (0.62) | NOTUMGAACES2ANO1ALDH1A1 | |
| SCHEMBL13753158 | 0.80 | DDR1 (0.47) | NOTUMGAACES2ANO1POLB | |
| SCHEMBL15726944 | 0.80 | ADCY8 (0.46) | NOTUMGAACES2ANO1HTT | |
| SCHEMBL19590866 | 0.79 | TP53 (0.43) | LMNADDR1CACNA1H | |
| SCHEMBL21697648 | 0.79 | RXRA (0.52) | NOTUMCES2ALDH1A1POLBMLYCD | |
| SCHEMBL17897037 | 0.79 | MRGPRX4 (0.51) | NOTUMCES2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9815851-B2 | Pyrrolo carboxamides as modulators of orphan nuclear receptor RAR-related orphan receptor-gamma (RORγ, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune diseases | PHENEX PHARMACEUTICALS AG (DE) | 2017-11-14 | — | — | US | disclosed |