Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20529569 | 0.82 | PLK4 (0.72) | ABCG2PLK4JAK2 | |
| SCHEMBL27965372 | 0.79 | JAK2 (0.52) | ROCK2HPGDALDH1A1MAPTHTT | |
| SCHEMBL17038109 | 0.76 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL28323047 | 0.75 | NAMPT (0.56) | HPGDALDH1A1MAPTHTTATM | |
| SCHEMBL28941887 | 0.75 | NPC1 (0.59) | HPGDALDH1A1MAPTFLT3ABCG2 | |
| SCHEMBL8150805 | 0.75 | HPGD (0.76) | HPGDALDH1A1MAPTSMN1; SMN2TSHR | |
| SCHEMBL2422608 | 0.75 | ABCG2 (0.72) | ALDH1A1MAPTATMKITROCK1 | |
| SCHEMBL19592079 | 0.74 | ROCK2 (0.63) | ROCK2ALDH1A1FLT3ROCK1PLK4 | |
| SCHEMBL34464779 | 0.74 | JAK2 (0.65) | ROCK2ROCK1PLK4JAK2 | |
| SCHEMBL28324046 | 0.73 | JAK2 (0.53) | HPGDALDH1A1MAPTHTTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108707151-A | Pyrimido-pyridazinone compound and application thereof | 阿萨纳生物科技有限责任公司 | 2018-10-26 | — | — | CN | claimed |
| CN-108601785-A | Purposes of the pyrimido pyridazinone in treating cancer | 阿沙纳生物科学公司 | 2018-09-28 | — | — | CN | claimed |
| CN-103974955-B | Pyrimido-pyridazinone compounds and uses thereof | 阿萨纳生物科技有限责任公司 | 2018-06-19 | — | — | CN | claimed |
| CN-108707151-A | Pyrimido-pyridazinone compound and application thereof | 阿萨纳生物科技有限责任公司 | 2018-10-26 | — | — | CN | disclosed |