Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | SCN1A | P35498 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23965931 | 0.87 | CYP2D6 (0.53) | CYP2D6TSHRKEAP1NFE2L2HRH3 | |
| SCHEMBL17727606 | 0.84 | CYP2D6 (0.54) | CYP2D6TSHRKEAP1NFE2L2HRH3 | |
| SCHEMBL11367106 | 0.81 | ALDH1A1 (0.56) | CYP2D6TSHRKEAP1NFE2L2HRH3 | |
| SCHEMBL11378620 | 0.80 | ALDH1A1 (0.55) | CYP2D6TSHRKEAP1NFE2L2HRH3 | |
| SCHEMBL23965963 | 0.78 | TSHR (0.43) | CYP2D6TSHRKEAP1NFE2L2HRH3 | |
| SCHEMBL4312079 | 0.78 | CYP2D6 (0.47) | CYP2D6TSHRKDM4EALDH1A1CYP1A2 | |
| SCHEMBL11376649 | 0.78 | CYP2D6 (0.77) | CYP2D6TSHRKEAP1NFE2L2KDM4E | |
| SCHEMBL11507359 | 0.77 | KDM4E (0.66) | CYP2D6TSHRKEAP1NFE2L2HRH3 | |
| SCHEMBL14216877 | 0.77 | ALDH1A1 (0.64) | CYP2D6TSHRKDM4ETDP1ALDH1A1 | |
| SCHEMBL30462836 | 0.77 | ALDH1A1 (0.64) | CYP2D6TSHRKDM4ETDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10035803-B2 | Synthesis of copanlisib and its dihydrochloride salt | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-07-31 | — | — | US | disclosed |
| US-20170327505-A1 | SYNTHESIS OF COPANLISIB AND ITS DIHYDROCHLORIDE SALT | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10035803-B2 | Synthesis of copanlisib and its dihydrochloride salt | COPS2, COPS6, COPS4 | CYP2D6 2194/4885TSHR 4063/4885KEAP1 2361/4885 |
| US-20170327505-A1 | SYNTHESIS OF COPANLISIB AND ITS DIHYDROCHLORIDE SALT | COPS2, COPS6, COPS4 | CYP2D6 2194/4885TSHR 4063/4885KEAP1 2361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.