Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17727606 | 0.95 | CYP2D6 (0.54) | CYP2D6CYP1A2CYP2C19SMN1; SMN2KDM4E | |
| SCHEMBL4320360 | 0.79 | MEN1 (0.57) | SMN1; SMN2NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL4314516 | 0.78 | MEN1 (0.43) | CYP2D6CYP1A2CYP2C19SMN1; SMN2KDM4E | |
| SCHEMBL4308230 | 0.78 | KMT2A (0.43) | CYP2D6CYP1A2CYP2C19SMN1; SMN2KDM4E | |
| SCHEMBL4320265 | 0.78 | RAB9A (0.38) | SMN1; SMN2KDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL31620997 | 0.78 | KDM4E (0.58) | CYP2D6CYP1A2CYP2C19SMN1; SMN2KDM4E | |
| SCHEMBL19600179 | 0.78 | CYP2D6 (0.54) | CYP2D6CYP1A2CYP2C19SMN1; SMN2KDM4E | |
| SCHEMBL4321227 | 0.77 | ALDH1A1 (0.59) | CYP2D6CYP1A2CYP2C19SMN1; SMN2KDM4E | |
| SCHEMBL10318577 | 0.77 | ALDH1A1 (0.59) | CYP2D6CYP1A2CYP2C19SMN1; SMN2KDM4E | |
| SCHEMBL29618260 | 0.77 | CYP2D6 (0.53) | CYP2D6CYP1A2CYP2C19SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605272-B2 | IGF-1R inhibitor | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2009-10-20 | — | — | US | disclosed |
| US-20090054508-A1 | IGF-1R INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-02-26 | — | — | US | disclosed |
| EP-1847532-A1 | IGF-1R INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-10-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054508-A1 | IGF-1R INHIBITOR | IGF1R, IGFBP5, IGFBP1 | CYP2D6 3041/4885CYP1A2 2250/4885CYP2C19 1774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.