Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL629729 | 0.89 | CYP11B1 (0.54) | CYP11B1CYP11B2PTGS2CYP19A1MAOA | |
| SCHEMBL21556956 | 0.80 | S1PR1 (0.44) | CYP11B1CYP11B2MAOBMAPT | |
| SCHEMBL11469458 | 0.79 | CYP11B1 (0.48) | CYP11B1CYP11B2PTGS2CYP19A1MAOA | |
| SCHEMBL19600977 | 0.78 | MCHR1 (0.38) | MCHR1ALDH1A1DRD2DRD3 | |
| SCHEMBL5904263 | 0.78 | MCHR1 (0.63) | CYP11B1CYP11B2PTGS2CYP19A1MCHR1 | |
| SCHEMBL223835 | 0.77 | CYP11B2 (0.56) | CYP11B1CYP11B2PTGS2CYP19A1MAOA | |
| SCHEMBL6822431 | 0.77 | CYP11B2 (0.63) | CYP11B1CYP11B2PTGS2CYP19A1 | |
| SCHEMBL11666679 | 0.77 | S1PR1 (0.49) | CYP11B1CYP11B2PTGS2CYP19A1MCHR1 | |
| SCHEMBL9448945 | 0.77 | ALOX5 (0.61) | CYP11B1CYP11B2PTGS2MCHR1 | |
| SCHEMBL636380 | 0.76 | MCHR1 (0.45) | CYP11B1CYP11B2PTGS2CYP19A1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170327439-A1 | DIHYDRONAPHTHALENE DERIVATIVE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2017-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170327439-A1 | DIHYDRONAPHTHALENE DERIVATIVE | S1PR5, LPAR5, S1PR1 | CYP11B1 854/4885CYP11B2 859/4885PTGS2 1941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.