Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 14/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9218186 | 0.89 | ALOX5 (0.47) | ALOX5PTGS2CYP11B1CYP11B2MCHR1 | |
| SCHEMBL9448870 | 0.88 | ALOX5 (0.48) | ALOX5PTGS2ALOX12PTGS1MCHR1 | |
| SCHEMBL9448907 | 0.86 | ALOX5 (0.60) | ALOX5PTGS2ALOX12PTGS1 | |
| SCHEMBL9448868 | 0.82 | ALOX5 (0.46) | ALOX5PTGS2ALOX12PTGS1 | |
| SCHEMBL9448809 | 0.82 | ALOX5 (0.46) | ALOX5PTGS2ALOX12PTGS1 | |
| SCHEMBL9729800 | 0.78 | ALOX5 (0.83) | ALOX5PTGS2ALOX12PTGS1 | |
| SCHEMBL11469458 | 0.78 | CYP11B1 (0.48) | PTGS2PTGS1CYP11B1CYP11B2MCHR1 | |
| SCHEMBL636380 | 0.77 | MCHR1 (0.45) | ALOX5PTGS2CYP11B1CYP11B2MCHR1 | |
| SCHEMBL19600975 | 0.77 | CYP11B1 (0.52) | PTGS2CYP11B1CYP11B2MCHR1 | |
| SCHEMBL11666679 | 0.75 | S1PR1 (0.49) | PTGS2CYP11B1CYP11B2MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5254731-A | Enzyme inhibitors; leukotriene disorders | GRUENENTHAL GMBH (DE) | 1993-10-19 | — | — | US | disclosed |