Sugi Predict

Sugi Predict / Compounds / SCHEMBL1960111

SCHEMBL1960111

SCHEMBL1960111

O=c1c2ccccc2nc(/C=C/c2ccccc2)n1-c1ccccc1

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 6/20 0.80
▸ KMT2A Q03164 6/20 0.80
▸ POLB P06746 4/20 0.80
▸ KLK7 P49862 1/20 0.80
▸ GFER P55789 1/20 0.78
▸ GAA P10253 1/20 0.74
▸ LMNA P02545 4/20 0.72
▸ TP53 P04637 3/20 0.72
▸ MAPT P10636 2/20 0.71
▸ KDM4E B2RXH2 3/20 0.70
▸ ALDH1A1 P00352 2/20 0.70
▸ BLM P54132 1/20 0.70
▸ TDP1 Q9NUW8 1/20 0.70
▸ L3MBTL1 Q9Y468 1/20 0.70
▸ THRB P10828 1/20 0.69
▸ NPC1 O15118 1/20 0.67
▸ RAB9A P51151 1/20 0.67
▸ SMN1; SMN2 Q16637 2/20 0.66
▸ USP2 O75604 1/20 0.66
▸ MAPK1 P28482 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31565645 1.00 MEN1 (0.80) MEN1KMT2APOLBKLK7GFER
SCHEMBL1960113 1.00 MEN1 (0.80) MEN1KMT2APOLBKLK7GFER
SCHEMBL2119658 0.92 MEN1 (0.95) MEN1KMT2APOLBKLK7GFER
SCHEMBL1965484 0.92 MEN1 (0.95) MEN1KMT2APOLBKLK7GFER
SCHEMBL1963762 0.92 MEN1 (0.72) MEN1KMT2APOLBKLK7GFER
SCHEMBL1963763 0.92 MEN1 (0.72) MEN1KMT2APOLBKLK7GFER
SCHEMBL1965482 0.92 MEN1 (0.95) MEN1KMT2APOLBKLK7GFER
SCHEMBL1961703 0.90 MEN1 (0.74) MEN1KMT2APOLBKLK7GFER
SCHEMBL1961700 0.90 MEN1 (0.74) MEN1KMT2APOLBKLK7GFER
SCHEMBL1962693 0.90 TP53 (0.76) MEN1KMT2APOLBKLK7GFER

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2964618-B1 QUINAZOLINONE ANTIBIOTICS UNIV NOTRE DAME DU LAC (US) 2019-09-04 — — EP disclosed
US-10329262-B2 Quinazolinone antibiotics UNIVERSITY OF NOTRE DAME DU LAC (US) 2019-06-25 — — US disclosed
US-20180029997-A1 QUINAZOLINONE ANTIBIOTICS UNIVERSITY OF NOTRE DAME DU LAC (US) 2018-02-01 — — US disclosed
US-20180029997-A1 QUINAZOLINONE ANTIBIOTICS UNIVERSITY OF NOTRE DAME DU LAC (US) 2018-02-01 — — US disclosed
US-9776975-B2 Quinazolinone antibiotics UNIVERSITY OF NOTRE DAME DU LAC (US) 2017-10-03 — — US disclosed
US-9776975-B2 Quinazolinone antibiotics UNIVERSITY OF NOTRE DAME DU LAC (US) 2017-10-03 — — US disclosed
US-20170224687-A1 COMPOUNDS FOR MODULATING TRPV3 FUNCTION HYDRA BIOSCIENCES INC (US) 2017-08-10 — — US disclosed
US-9486455-B2 Compounds for modulating TRPV3 function HYDRA BIOSCIENCES, INC. (US) 2016-11-08 — — US disclosed
US-20160031832-A1 QUINAZOLINONE ANTIBIOTICS UNIVERSITY OF NOTRE DAME DU LAC (US) 2016-02-04 — — US disclosed
US-20160031832-A1 QUINAZOLINONE ANTIBIOTICS UNIVERSITY OF NOTRE DAME DU LAC (US) 2016-02-04 — — US disclosed
US-20100152209-A1 Compounds for Modulating TRPV3 Function HYDRA BIOSCIENCES INC. (US) 2010-06-17 — — US disclosed
EP-1954283-A2 COMPOUNDS FOR MODULATING TRPV3 FUNCTION Hydra Biosciences, Inc. (US) 2008-08-13 — — EP disclosed
US-20070179164-A1 Compounds for modulating TRPV3 function HYDRA BIOSCIENCES, INC. (US) 2007-08-02 — — US disclosed
US-20070179164-A1 Compounds for modulating TRPV3 function HYDRA BIOSCIENCES, INC. (US) 2007-08-02 — — US disclosed
US-20070179164-A1 Compounds for modulating TRPV3 function HYDRA BIOSCIENCES, INC. (US) 2007-08-02 — — US disclosed
WO-2007056124-A2 COMPOUNDS FOR MODULATING TRPV3 FUNCTION HYDRA BIOSCIENCES, INC. (US) 2007-05-18 — — WO disclosed
WO-2007056124-A2 COMPOUNDS FOR MODULATING TRPV3 FUNCTION HYDRA BIOSCIENCES, INC. (US) 2007-05-18 — — WO disclosed
US-7053216-B2 Modulators of Rho C activity ICONIX PHARMACEUTICALS, INC. (US) 2006-05-30 — — US disclosed
US-20030171387-A1 Modulators of Rho C activity ENTELOS HOLDING CORP. 2003-09-11 — — US disclosed
WO-2003043961-A2 MODULATORS OF RHO C ACTIVITY ICONIX PHARMACEUTICALS, INC. (US) 2003-05-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030171387-A1 Modulators of Rho C activity RHOC, ROCK1, CIT MEN1 4684/4885KMT2A 3564/4885POLB 3377/4885
US-20100152209-A1 Compounds for Modulating TRPV3 Function TRPV3, TRPV1, TRPV4 MEN1 4683/4885KMT2A 4347/4885POLB 4849/4885
US-20070179164-A1 Compounds for modulating TRPV3 function TRPV3, TRPV1, TRPV4 MEN1 4683/4885KMT2A 4347/4885POLB 4849/4885
US-20170224687-A1 COMPOUNDS FOR MODULATING TRPV3 FUNCTION TRPV3, TRPV1, TRPV4 MEN1 4683/4885KMT2A 4347/4885POLB 4849/4885
US-10329262-B2 Quinazolinone antibiotics Q6ZSR9, CEP170, TOP2A MEN1 4808/4885KMT2A 3019/4885POLB 122/4885
US-20160031832-A1 QUINAZOLINONE ANTIBIOTICS Q6ZSR9, TOP2A, CEP170 MEN1 4776/4885KMT2A 2228/4885POLB 176/4885
US-20180029997-A1 QUINAZOLINONE ANTIBIOTICS Q6ZSR9, TOP2A, CEP170 MEN1 4776/4885KMT2A 2228/4885POLB 176/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.