Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19582634 | 0.78 | MMP1 (0.46) | LMNAKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL19582553 | 0.72 | KDM4E (0.49) | LMNARAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL6802528 | 0.69 | DPP7 (0.35) | THRBMC4RKMT2AMEN1ALDH1A1 | |
| SCHEMBL6378630 | 0.69 | ALDH1A1 (0.52) | LMNANPC1RAB9AEPHX1KMT2A | |
| SCHEMBL16838973 | 0.69 | HSD11B1 (0.41) | NPC1RAB9AEPHX1KMT2AMEN1 | |
| SCHEMBL31135123 | 0.68 | USP2 (0.37) | LMNAALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6378763 | 0.68 | ALDH1A1 (0.51) | LMNANPC1RAB9AEPHX1KMT2A | |
| SCHEMBL16838963 | 0.68 | ALDH1A1 (0.42) | SLC6A2SLC6A4SLC6A3LMNANPC1 | |
| SCHEMBL10643722 | 0.65 | SMN1; SMN2 (0.42) | LMNAKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL415949 | 0.64 | CHRM2 (0.67) | LMNATHRBKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10030020-B2 | Spirocycle compounds and methods of making and using same | ABIDE THERAPEUTICS, INC. (US) | 2018-07-24 | — | — | US | disclosed |
| US-20170327500-A1 | SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME | H. LUNDBECK A/S (DK) | 2017-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170327500-A1 | SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ABHD6, ABHD16A, ACSL6 | SLC6A2 2504/4885SLC6A4 2371/4885SLC6A3 1038/4885 |
| US-10030020-B2 | Spirocycle compounds and methods of making and using same | ABHD6, ABHD16A, ACSL6 | SLC6A2 2504/4885SLC6A4 2371/4885SLC6A3 1038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.