Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.35 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.35 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | WNK1 | Q9H4A3 | 2/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25972655 | 0.76 | FGFR1 (0.37) | ALDH1A1MAPTMEN1KMT2ANPC1 | |
| SCHEMBL113156 | 0.75 | POLB (0.41) | ALDH1A1MAPTMEN1KMT2ANPC1 | |
| SCHEMBL31586213 | 0.72 | RET (0.36) | ALDH1A1POLBCYP1A2 | |
| SCHEMBL22235822 | 0.72 | GAA (0.36) | ALDH1A1KMT2APOLBHPGDGAA | |
| SCHEMBL165273 | 0.71 | RXRA (0.40) | ALDH1A1MAPTMEN1KMT2ANPC1 | |
| SCHEMBL2571450 | 0.70 | CYP4F2 (0.33) | ALDH1A1MAPTMEN1KMT2ANPC1 | |
| SCHEMBL22235827 | 0.69 | DGAT2 (0.34) | ALDH1A1MAPTMEN1KMT2ANPC1 | |
| SCHEMBL320891 | 0.69 | ALDH1A1 (0.42) | EGFRALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL29258348 | 0.67 | L3MBTL1 (0.37) | ALDH1A1MAPTMEN1KMT2ANPC1 | |
| SCHEMBL458489 | 0.67 | ALDH1A1 (0.37) | ALDH1A1MAPTMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507231-A1 | INDAZOLE DERIVATIVES AS PI 3 - KINASE INHIBITORS | Glaxo Group Limited (GB) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011067366-A1 | INDAZOLE DERIVATIVES AS PI 3 - KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2011-06-09 | — | — | WO | disclosed |