Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.35 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.35 |
| ▸ | NPR3 | P17342 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365645 | 1.00 | CYP2D6 (0.41) | CYP2D6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL7871486 | 0.83 | CYP2D6 (0.42) | CYP2D6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL22398849 | 0.83 | CYP2D6 (0.42) | CYP2D6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL17995262 | 0.83 | CYP2D6 (0.42) | CYP2D6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL20632486 | 0.82 | CYP2D6 (0.40) | CYP2D6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL11938285 | 0.82 | L3MBTL1 (0.36) | CYP2D6TDP1MAPTGAAPOLB | |
| Hydrochloric Acid SCHEMBL7268530 | 0.81 | CYP2D6 (0.41) | CYP2D6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL8284484 | 0.81 | TDP1 (0.37) | TDP1MAPTGAAPOLBNPSR1 | |
| SCHEMBL10209050 | 0.81 | CTSK (0.41) | TDP1MAPTGAAPOLBNPSR1 | |
| SCHEMBL25453619 | 0.80 | CYP2D6 (0.44) | CYP2D6HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125025-B1 | MULTI-FUNCTIONAL DRUG CARRIERS | NITTO DENKO CORP (JP) | 2012-11-14 | — | — | EP | disclosed |
| WO-2012027204-A1 | END-CAPPED POLYMERS | NITTO DENKO CORPORATION (JP) | 2012-03-01 | — | — | WO | disclosed |
| EP-2206736-B1 | Polyglutamate-amino acid conjugates and methods | NITTO DENKO CORP (JP) | 2012-02-08 | — | — | EP | disclosed |
| WO-2011112733-A1 | CARBOHYDRATE-POLYAMINO ACID-DRUG CONJUGATES | NITTO DENKO CORPORATION (JP) | 2011-09-15 | — | — | WO | disclosed |
| US-20110224148-A1 | CARBOHYDRATE-POLYAMINO ACID-DRUG CONJUGATES | NITTO DENKO CORPORATION (JP) | 2011-09-15 | — | — | US | disclosed |
| EP-2325232-A1 | Polyglutamate-amino acid conjugates and methods | Nitto Denko Corporation (JP) | 2011-05-25 | — | — | EP | disclosed |
| EP-2206736-A1 | Polyglutamate-amino acid conjugates and methods | Nitto Denko Corporation (JP) | 2010-07-14 | — | — | EP | disclosed |
| WO-2010029760-A1 | IMAGING AGENTS OF FIBROTIC DISEASES | NITTO DENKO CORPORATION (JP) | 2010-03-18 | — | — | WO | disclosed |
| EP-1969031-B1 | POLYGLUTAMATE-AMINO ACID CONJUGATES AND METHODS | NITTO DENKO CORP (JP) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008141111-A2 | POLYMERS CONJUGATED WITH PLATINUM DRUGS | NITTO DENKO CORPORATION (JP) | 2008-11-20 | — | — | WO | disclosed |
| WO-2008141107-A2 | COMPOSITIONS THAT INCLUDE A HYDROPHOBIC COMPOUND AND A POLYAMINO ACID CONJUGATE | NITTO DENKO CORPORATION (JP) | 2008-11-20 | — | — | WO | disclosed |
| WO-2008141110-A2 | POLYGLUTAMATE CONJUGATES AND POLYGLUTAMATE-AMINO ACID CONJUGATES HAVING A PLURALITY OF DRUGS | NITTO DENKO CORPORATION (JP) | 2008-11-20 | — | — | WO | disclosed |
| WO-2008094834-A2 | MULTI-FUNCTIONAL DRUG CARRIERS | NITTO DENKO CORPORATION (JP) | 2008-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224148-A1 | CARBOHYDRATE-POLYAMINO ACID-DRUG CONJUGATES | CSGALNACT1, FUT6, FUT5 | CYP2D6 2707/4885HDAC3 183/4885HDAC1 311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.