Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.34 |
| ▸ | PLG | P00747 | 2/20 | 0.33 |
| ▸ | PLAU | P00749 | 2/20 | 0.33 |
| ▸ | PLAT | P00750 | 2/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | FSHR | P23945 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2018116 | 0.89 | MAPT (0.36) | CNR1CNR2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL1962784 | 0.86 | CNR1 (0.38) | CNR1CNR2MCHR1FSHRRORC | |
| SCHEMBL1961020 | 0.82 | P2RY14 (0.40) | ALDH1A1MAPTSMN1; SMN2MEN1CYP3A4 | |
| SCHEMBL8772192 | 0.82 | P2RY14 (0.40) | ALDH1A1MAPTSMN1; SMN2MEN1CYP3A4 | |
| SCHEMBL6113620 | 0.79 | P2RY14 (0.40) | ALDH1A1MAPTSMN1; SMN2MEN1CYP3A4 | |
| SCHEMBL6113618 | 0.79 | P2RY14 (0.40) | ALDH1A1MAPTSMN1; SMN2MEN1CYP3A4 | |
| SCHEMBL6113741 | 0.76 | CNR1 (0.34) | CNR1CNR2ALDH1A1MAPTMEN1 | |
| SCHEMBL1960938 | 0.76 | MEN1 (0.44) | MAPTMEN1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL18754293 | 0.74 | P2RX1 (0.49) | MAPTMEN1KMT2ATRPA1FSHR | |
| SCHEMBL2018115 | 0.71 | P2RY14 (0.39) | ALDH1A1MAPTSMN1; SMN2MEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651913-B1 | INDENO-FUSED RING COMPOUNDS HAVING PHOTOCHROMIC PROPERTIES | TRANSITIONS OPTICAL INC (US) | 2017-04-19 | — | — | EP | disclosed |
| US-9309455-B2 | Indeno-fused ring compounds | TRANSITIONS OPTICAL, INC. (US) | 2016-04-12 | — | — | US | disclosed |
| US-20140166948-A1 | INDENO-FUSED RING COMPOUNDS | TRANSITIONS OPTICAL LIMITED (IE) | 2014-06-19 | — | — | US | disclosed |
| US-8698117-B2 | Indeno-fused ring compounds | TRANSITIONS OPTICAL, INC. (US) | 2014-04-15 | — | — | US | disclosed |
| US-8545984-B2 | Photochromic compounds and compositions | TRANSITIONS OPTICAL, INC. (US) | 2013-10-01 | — | — | US | disclosed |
| US-20120126185-A1 | INDENO-FUSED RING COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2012-05-24 | — | — | US | disclosed |
| US-20110140056-A1 | Indeno-fused ring compounds | TRANSITIONS OPTICAL, INC. (US) | 2011-06-16 | — | — | US | disclosed |
| US-20110129678-A1 | Photochromic compounds and compositions | TRANSITIONS OPTICAL, INC. (US) | 2011-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110140056-A1 | Indeno-fused ring compounds | CRY2, SQOR, INTS6 | CNR1 1095/4885CNR2 218/4885ALDH1A1 498/4885 |
| US-20110129678-A1 | Photochromic compounds and compositions | CRY2, CRY1, PPOX | CNR1 1788/4885CNR2 1214/4885ALDH1A1 1243/4885 |
| US-20120126185-A1 | INDENO-FUSED RING COMPOUNDS | CRY2, SQOR, INTS6 | CNR1 1095/4885CNR2 218/4885ALDH1A1 498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.