Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.61 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.54 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.53 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | DRD5 | P21918 | 1/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.50 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2437081 | 0.91 | PRMT5 (0.56) | SIGMAR1DRD2HRH3PRMT5WDR77 | |
| SCHEMBL4924953 | 0.90 | DRD1 (0.58) | SIGMAR1DRD2HRH3DRD1DRD5 | |
| Hydrochloric Acid SCHEMBL14974971 | 0.90 | PRMT5 (0.55) | SIGMAR1DRD2HRH3PRMT5WDR77 | |
| SCHEMBL38653251 | 0.89 | PRMT5 (0.54) | SIGMAR1DRD2HRH3PRMT5WDR77 | |
| Hydrochloric Acid SCHEMBL11466311 | 0.89 | DRD1 (0.57) | SIGMAR1DRD2HRH3DRD1DRD5 | |
| SCHEMBL38653916 | 0.81 | DRD2 (0.59) | DRD2HRH3DRD1DRD5PRMT5 | |
| SCHEMBL10733843 | 0.80 | SIGMAR1 (0.52) | SIGMAR1DRD2OPRM1OPRL1OPRK1 | |
| SCHEMBL1868503 | 0.80 | OPRL1 (0.60) | SIGMAR1DRD2OPRM1OPRL1OPRK1 | |
| SCHEMBL23004926 | 0.78 | ACHE (0.68) | DRD2PRMT5WDR77 | |
| SCHEMBL11455795 | 0.78 | HRH3 (0.54) | SIGMAR1DRD2OPRL1OPRK1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8207160-B2 | Tetrahydrobenzazepines and their use in he modulation of the dopamine D3 receptor | ABBOTT GMBH & CO. KG (DE) | 2012-06-26 | — | — | US | disclosed |
| EP-1694334-B1 | TETRAHYDROBENZAZEPINES AND THEIR USE IN THE MODULATION OF THE DOPAMINE D3 RECEPTOR | ABBOTT GMBH & CO KG (DE) | 2011-10-19 | — | — | EP | disclosed |
| EP-2332543-A1 | Tetrahydrobenzazepines and their use in the modulation of the dopamine D3 receptor | Abbott GmbH & Co. KG (DE) | 2011-06-15 | — | — | EP | disclosed |
| EP-1694334-A1 | TETRAHYDROBENZAZEPINES AND THEIR USE IN THE MODULATION OF THE DOPAMINE D3 RECEPTOR | Abbott GmbH & Co. KG (DE) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005058328-A1 | TETRAHYDROBENZAZEPINES AND THEIR USE IN THE MODULATION OF THE DOPAMINE D3 RECEPTOR | ABBOTT GMBH & CO. KG (DE) | 2005-06-30 | — | — | WO | disclosed |
| US-20050137186-A1 | Tetrahydrobenzazepines and their use | ABBOTT GMBH & CO. KG. | 2005-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050137186-A1 | Tetrahydrobenzazepines and their use | DRD3, ADRB3, AVPR1B | SIGMAR1 124/4885DRD2 9/4885CHRM5 205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.