Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.56 |
| ▸ | PPARA | Q07869 | 6/20 | 0.52 |
| ▸ | KDM5A | P29375 | 6/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 6/20 | 0.49 |
| ▸ | KDM5B | Q9UGL1 | 6/20 | 0.49 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19631870 | 0.93 | KDM4C (0.48) | NR4A2PPARAKDM5AKDM4CKDM5B | |
| SCHEMBL19615520 | 0.93 | NR4A2 (0.61) | NR4A2PPARAKDM5AKDM4CKDM5B | |
| SCHEMBL19616535 | 0.91 | NR4A2 (0.56) | NR4A2PPARAKDM5AKDM4CKDM5B | |
| SCHEMBL19615641 | 0.90 | PLA2G4B (0.54) | NR4A2KDM5AKDM4CKDM5BMAOB | |
| SCHEMBL19632270 | 0.86 | NR4A2 (0.61) | NR4A2PPARAKDM5AKDM4CKDM5B | |
| SCHEMBL19615441 | 0.83 | NR4A2 (0.57) | NR4A2MAOBPLA2G4B | |
| SCHEMBL19615660 | 0.83 | NR4A2 (0.60) | NR4A2PPARAKDM5AKDM4CKDM5B | |
| SCHEMBL19631994 | 0.82 | KDM6B (0.51) | NR4A2KDM5AKDM4CKDM5BPLA2G4B | |
| SCHEMBL19615650 | 0.82 | NR4A2 (0.52) | NR4A2KDM5AKDM4CKDM5BPLA2G4B | |
| SCHEMBL19615734 | 0.82 | KDM4C (0.48) | PPARAKDM5AKDM4CKDM5BKDM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017198785-A1 | OXIME DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASE KDM4C | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-11-23 | — | — | WO | claimed |
| WO-2017198785-A1 | OXIME DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASE KDM4C | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-11-23 | — | — | WO | disclosed |
| WO-2017198785-A1 | OXIME DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASE KDM4C | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-11-23 | — | — | WO | disclosed |