⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19616876 | 0.81 | PRKAB2 (0.32) | — | |
| SCHEMBL19616582 | 0.81 | MAPK8 (0.30) | — | |
| SCHEMBL19616539 | 0.79 | CHUK (0.36) | — | |
| SCHEMBL19616623 | 0.79 | MAPK8 (0.33) | — | |
| SCHEMBL14721720 | 0.72 | PRKAG1 (0.33) | — | |
| SCHEMBL31586483 | 0.71 | GAA (0.38) | — | |
| SCHEMBL3402451 | 0.71 | GAA (0.44) | — | |
| SCHEMBL31162538 | 0.68 | PDE10A (0.33) | — | |
| SCHEMBL31190772 | 0.68 | PIM1 (0.33) | — | |
| SCHEMBL15740705 | 0.68 | PIM1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3908283-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2021-11-17 | — | — | EP | disclosed |
| EP-3844151-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2021-07-07 | — | — | EP | disclosed |
| EP-3710439-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2020-09-23 | — | — | EP | disclosed |
| WO-2020146613-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2020-07-16 | — | — | WO | disclosed |
| WO-2020047192-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2020-03-05 | — | — | WO | disclosed |
| EP-3458445-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2019-03-27 | — | — | EP | disclosed |
| WO-2017201161-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2017-11-23 | — | — | WO | disclosed |