Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 3/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | PTAFR | P25105 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19620342 | 0.89 | MDM2 (0.36) | PLA2G7MDM2MEN1MAPTKMT2A | |
| SCHEMBL19620522 | 0.88 | KDM4E (0.42) | MDM2MEN1MAPTKMT2A | |
| SCHEMBL19620490 | 0.87 | ADK (0.38) | DAOMEN1MAPTKMT2A | |
| SCHEMBL19620505 | 0.84 | LMNA (0.37) | TP53DAOMEN1MAPTKMT2A | |
| SCHEMBL19620650 | 0.83 | CYP19A1 (0.42) | PLA2G7CYP19A1TP53MDM2MAPT | |
| SCHEMBL19620548 | 0.82 | MEN1 (0.40) | TP53MEN1MAPTKMT2A | |
| SCHEMBL19620609 | 0.82 | MDM2 (0.38) | TP53MDM2MAPT | |
| SCHEMBL19620581 | 0.82 | MAPT (0.38) | TP53DAOMEN1MAPTKMT2A | |
| SCHEMBL19620634 | 0.82 | MDM2 (0.35) | MDM2DAOMEN1MAPTKMT2A | |
| SCHEMBL19620607 | 0.81 | KDM4E (0.33) | MDM2DAOMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3345596-A2 | INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER | RHODE ISLAND HOSPITAL (US) | 2018-07-11 | — | — | EP | disclosed |
| EP-2897607-B1 | INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER | RHODE ISLAND HOSPITAL (US) | 2017-11-22 | — | — | EP | disclosed |