Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24698949 | 0.85 | SYK (0.38) | DGAT2CYP11B2ALDH1A1BRD4 | |
| SCHEMBL24698468 | 0.83 | CA1 (0.42) | GBA1 | |
| SCHEMBL19623475 | 0.80 | ACHE (0.51) | IGF1RLMNAMAPTGBA1APP | |
| SCHEMBL19623831 | 0.78 | PIK3CA (0.49) | IGF1RLMNAMAPTALDH1A1RAB9A | |
| SCHEMBL19623781 | 0.78 | KMT2A (0.46) | IGF1RMAPTGBA1APPBCHE | |
| SCHEMBL24697549 | 0.76 | PIK3CA (0.54) | GBA1MEN1KMT2ABRD4 | |
| SCHEMBL24698300 | 0.76 | IGF1R (0.40) | IGF1RLMNAMAPTGBA1APP | |
| SCHEMBL24698819 | 0.75 | PRMT6 (0.44) | IGF1RLMNAGBA1ALDH1A1 | |
| SCHEMBL24697805 | 0.74 | CASP1 (0.44) | LMNAALDH1A1KMT2A | |
| SCHEMBL24697555 | 0.74 | PIK3CA (0.49) | IGF1RLMNAGBA1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050749-B1 | PYRIMIDINE DERIVATIVE AS PI3K INHIBITOR AND USE THEREOF | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2017-11-22 | — | — | EP | disclosed |