Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 3/20 | 0.44 |
| ▸ | CASP5 | P51878 | 3/20 | 0.44 |
| ▸ | CASP4 | P49662 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ACP1 | P24666 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24699446 | 0.99 | CASP1 (0.45) | CASP1CASP5CASP4LMNAHTT | |
| SCHEMBL24698793 | 0.98 | CASP1 (0.43) | CASP1CASP5CASP4LMNAHTT | |
| SCHEMBL19623707 | 0.91 | CASP1 (0.40) | CASP1CASP5CASP4LMNAHTT | |
| SCHEMBL24698176 | 0.90 | KDM4E (0.44) | HTTALDH1A1DRD2DRD4DRD3 | |
| SCHEMBL24698194 | 0.87 | LMNA (0.38) | CASP1CASP5CASP4LMNAHTT | |
| SCHEMBL24699003 | 0.86 | PRMT6 (0.39) | CASP1CASP5LMNAHTTSMN1; SMN2 | |
| SCHEMBL24697803 | 0.84 | ACP1 (0.41) | SMN1; SMN2ALDH1A1ACP1TDP1CYP2D6 | |
| SCHEMBL30016293 | 0.84 | ACP1 (0.41) | SMN1; SMN2ALDH1A1ACP1TDP1CYP2D6 | |
| SCHEMBL24699383 | 0.84 | LMNA (0.35) | CASP1CASP5CASP4LMNAHTT | |
| SCHEMBL24698819 | 0.83 | PRMT6 (0.44) | LMNAHTTSMN1; SMN2ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |