Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL375687 | 0.85 | PDE4B (0.44) | EGFRALDH1A1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL31469077 | 0.85 | SYK (0.41) | POLBEGFRRAB9ACDK1CDK5 | |
| SCHEMBL13211477 | 0.82 | HPGD (0.46) | POLBALDH1A1NPC1RAB9AGAA | |
| SCHEMBL3938216 | 0.81 | RHOA (0.46) | EGFRALDH1A1NPC1RAB9AGAA | |
| SCHEMBL31083985 | 0.81 | MAPK1 (0.49) | POLBALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL3517759 | 0.76 | CCNT1 (0.49) | CDK1CCNB1CCNA2CDK2HPGD | |
| SCHEMBL589243 | 0.75 | PLK4 (0.44) | EGFRALDH1A1CDK1SMN1; SMN2 | |
| SCHEMBL31491328 | 0.75 | KIF11 (0.41) | POLBALDH1A1NPC1RAB9ACA12 | |
| SCHEMBL13638690 | 0.73 | NPC1 (0.35) | POLBALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29056205 | 0.73 | PDE4B (0.50) | EGFRABCB1ABCG2GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2400961-B1 | MEDICINE COMBINATIONS CONTAINING PDE4 INHIBITORS AND NSAIDS | BOEHRINGER INGELHEIM INT (DE) | 2017-11-22 | — | — | EP | disclosed |