Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 12/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 7/20 | 0.46 |
| ▸ | RXRB | P28702 | 6/20 | 0.46 |
| ▸ | RXRG | P48443 | 4/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 3/20 | 0.46 |
| ▸ | NR4A3 | Q92570 | 3/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | C5 | P01031 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7498583 | 0.85 | PTGS2 (0.69) | PTGS2PTGS1 | |
| SCHEMBL19625454 | 0.84 | NPC1 (0.52) | NR4A2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL19625355 | 0.84 | RXRA (0.43) | NR4A2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL13081228 | 0.83 | NR4A2 (0.49) | NR4A2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL821305 | 0.81 | KDM4E (0.50) | NR4A2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL8146420 | 0.81 | NR4A2 (0.55) | NR4A2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL9452959 | 0.79 | NR4A2 (0.49) | NR4A2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL8151850 | 0.77 | RXRA (0.51) | NR4A2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL8140604 | 0.77 | RXRA (0.51) | NR4A2MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL2091239 | 0.75 | MAPK13 (0.83) | NR4A2MAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10472360-B2 | Purine diones as Wnt pathway modulators | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2019-11-12 | — | — | US | disclosed |
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-11-23 | — | — | US | disclosed |
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | WNT1, WNT3A, CTNNB1 | NR4A2 266/4885MAPK13 1744/4885MAPK12 1157/4885 |
| US-10472360-B2 | Purine diones as Wnt pathway modulators | WNT1, WNT3A, CTNNB1 | NR4A2 266/4885MAPK13 1744/4885MAPK12 1157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.