Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | COMT | P21964 | 1/20 | 0.37 |
| ▸ | MPL | P40238 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19626497 | 0.85 | ALDH1A1 (0.49) | CYP3A4ALDH1A1RAB9AMEN1NPC1 | |
| SCHEMBL19625369 | 0.85 | MAPT (0.38) | CYP3A4ALDH1A1RAB9AMEN1NPC1 | |
| SCHEMBL19625433 | 0.84 | CDC25A (0.39) | ALDH1A1RAB9AMEN1NPC1KMT2A | |
| SCHEMBL2573085 | 0.83 | RAB9A (0.57) | CYP3A4ALDH1A1RAB9AMEN1NPC1 | |
| SCHEMBL19625441 | 0.82 | ABL1 (0.38) | CYP3A4ALDH1A1RAB9AMEN1NPC1 | |
| SCHEMBL19626611 | 0.81 | GAA (0.40) | ALDH1A1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL19625390 | 0.81 | LATS1 (0.35) | ALDH1A1RAB9AMEN1NPC1KMT2A | |
| SCHEMBL19625435 | 0.79 | CDC25A (0.39) | ALDH1A1RAB9AMEN1NPC1KMT2A | |
| SCHEMBL19625374 | 0.79 | GFER (0.43) | CYP3A4ALDH1A1RAB9AMEN1NPC1 | |
| SCHEMBL19625501 | 0.79 | COMT (0.36) | CYP3A4ALDH1A1RAB9AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10472360-B2 | Purine diones as Wnt pathway modulators | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2019-11-12 | — | — | US | disclosed |
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-11-23 | — | — | US | disclosed |
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | WNT1, WNT3A, CTNNB1 | CYP3A4 419/4885ALDH1A1 1166/4885RAB9A 3162/4885 |
| US-10472360-B2 | Purine diones as Wnt pathway modulators | WNT1, WNT3A, CTNNB1 | CYP3A4 419/4885ALDH1A1 1166/4885RAB9A 3162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.