Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | PHGDH | O43175 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15726987 | 0.81 | ALDH1A1 (0.41) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1687958 | 0.81 | ALDH1A1 (0.41) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15080935 | 0.81 | ALDH1A1 (0.41) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10285827 | 0.77 | LMNA (0.44) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23997789 | 0.76 | ALDH1A1 (0.47) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27889775 | 0.73 | ALDH1A1 (0.48) | ALDH1A1NPC1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL25206318 | 0.73 | JAK3 (0.38) | ALDH1A1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12142184 | 0.71 | — | — | |
| SCHEMBL3409523 | 0.71 | — | — | |
| SCHEMBL6037523 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10590498-B2 | Compounds for reactivation of acetylcholinesterase and related compositions methods and systems | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (US) | 2020-03-17 | — | — | US | disclosed |
| US-20170335415-A1 | COMPOUNDS FOR REACTIVATION OF ACETYLCHOLINESTERASE AND RELATED COMPOSITIONS METHODS AND SYSTEMS | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10590498-B2 | Compounds for reactivation of acetylcholinesterase and related compositions methods and systems | ACHE, BCHE, CHAT | ALDH1A1 440/4885HPGD 470/4885NPC1 1591/4885 |
| US-20170335415-A1 | COMPOUNDS FOR REACTIVATION OF ACETYLCHOLINESTERASE AND RELATED COMPOSITIONS METHODS AND SYSTEMS | ACHE, BCHE, CHAT | ALDH1A1 440/4885HPGD 470/4885NPC1 1591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.