Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10349652 | 0.81 | PDE10A (0.40) | PDE10AGSK3BDRD2DRD3KDM4E | |
| Hydrochloric Acid SCHEMBL10382640 | 0.80 | GSK3B (0.40) | PDE10AGSK3BDRD2DRD3KDM4E | |
| SCHEMBL21498090 | 0.79 | KDM4E (0.40) | PDE10AGSK3BKDM4EMEN1KMT2A | |
| SCHEMBL11707727 | 0.78 | OPRD1 (0.37) | PDE10AGSK3BOPRM1OPRD1KDM4E | |
| SCHEMBL7013419 | 0.72 | GSK3B (0.42) | PDE10AGSK3BDRD2DRD3DRD1 | |
| SCHEMBL2908444 | 0.70 | PDE10A (0.45) | PDE10AGSK3BKDM4EDRD1 | |
| SCHEMBL90572 | 0.70 | PDE10A (0.45) | PDE10AGSK3BKDM4EDRD1 | |
| SCHEMBL2910280 | 0.70 | PDE10A (0.45) | PDE10AGSK3BKDM4EDRD1 | |
| SCHEMBL22222379 | 0.69 | CACNA2D1 (0.32) | OPRM1 | |
| SCHEMBL21831322 | 0.69 | HRH3 (0.47) | OPRM1OPRD1OPRK1OPRL1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10358437-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2019-07-23 | — | — | US | disclosed |
| US-10316023-B2 | — | — | 2019-06-11 | — | — | US | disclosed |
| US-20170334883-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10316023-B2 | — | PKD1, NHERF1, PCSK6 | PDE10A 278/4885GSK3B 1867/4885OPRM1 2947/4885 |
| US-20170334883-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | PKD1, NHERF1, HDAC10 | PDE10A 123/4885GSK3B 1607/4885OPRM1 3220/4885 |
| US-10358437-B2 | Therapeutic compounds and uses thereof | PKD1, NHERF1, HDAC10 | PDE10A 123/4885GSK3B 1607/4885OPRM1 3220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.