Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | TMPRSS4 | Q9NRS4 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.40 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.40 |
| ▸ | GPR6 | P46095 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17779115 | 0.81 | TMPRSS4 (0.47) | PDK1PDK2PDK3PDK4TMPRSS4 | |
| SCHEMBL17770420 | 0.80 | TMPRSS4 (0.46) | PDK1PDK2PDK3PDK4TMPRSS4 | |
| SCHEMBL19630853 | 0.79 | P2RX7 (0.47) | TMPRSS4GPR6MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL17770334 | 0.79 | TMPRSS4 (0.46) | PDK1PDK2PDK3PDK4TMPRSS4 | |
| SCHEMBL17770333 | 0.79 | TMPRSS4 (0.46) | PDK1PDK2PDK3PDK4TMPRSS4 | |
| SCHEMBL17770439 | 0.77 | HDAC1 (0.42) | PDK1PDK2PDK3PDK4TMPRSS4 | |
| Monoethanolamine SCHEMBL19612175 | 0.77 | TMPRSS4 (0.60) | TMPRSS4NPC1ALDH1A1RAB9AKDM4E | |
| SCHEMBL30771735 | 0.77 | TMPRSS4 (0.70) | PDK1PDK2PDK3PDK4TMPRSS4 | |
| SCHEMBL14885885 | 0.77 | TMPRSS4 (0.70) | PDK1PDK2PDK3PDK4TMPRSS4 | |
| SCHEMBL17770385 | 0.76 | GPR6 (0.42) | PDK1PDK2PDK3PDK4TMPRSS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10227315-B2 | Mitochondrial uncouplers for treatment of metabolic diseases and cancer | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2019-03-12 | — | — | US | disclosed |
| US-20170334869-A1 | NOVEL MITOCHONDRIAL UNCOUPLERS FOR TREATMENT OF METABOLIC DISEASES AND CANCER | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10227315-B2 | Mitochondrial uncouplers for treatment of metabolic diseases and cancer | AK2, PC, GLS2 | PDK1 111/4885PDK2 106/4885PDK3 197/4885 |
| US-20170334869-A1 | NOVEL MITOCHONDRIAL UNCOUPLERS FOR TREATMENT OF METABOLIC DISEASES AND CANCER | AK2, PC, GLS2 | PDK1 87/4885PDK2 100/4885PDK3 156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.