Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24399159 | 0.90 | ALDH1A1 (0.42) | HDAC1HDAC8HDAC6ALDH1A1L3MBTL1 | |
| SCHEMBL12543528 | 0.89 | HDAC1 (0.51) | HDAC1HDAC8HDAC6ALDH1A1L3MBTL1 | |
| SCHEMBL30801697 | 0.88 | HDAC1 (0.45) | HDAC1HDAC8HDAC6ALDH1A1L3MBTL1 | |
| SCHEMBL5423537 | 0.85 | HDAC1 (0.44) | HDAC1HDAC8HDAC6ALDH1A1L3MBTL1 | |
| SCHEMBL17361113 | 0.85 | USP30 (0.35) | HDAC1HDAC8HDAC6ALDH1A1MMP13 | |
| SCHEMBL1963140 | 0.82 | AADAT (0.49) | ALDH1A1L3MBTL1GAACYP3A4HPGD | |
| SCHEMBL1960250 | 0.81 | HDAC1 (0.42) | HDAC1HDAC8HDAC6ALDH1A1L3MBTL1 | |
| SCHEMBL17761442 | 0.79 | HDAC1 (0.54) | HDAC1HDAC8HDAC6ALDH1A1L3MBTL1 | |
| SCHEMBL17371377 | 0.78 | USP30 (0.41) | MAPTSMN1; SMN2MMP13MMP2MMP14 | |
| SCHEMBL22770534 | 0.77 | ALDH1A1 (0.46) | HDAC1HDAC8HDAC6ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160159800-A1 | MK2 INHIBITORS | N.V. ORGANON (NL) | 2016-06-09 | — | — | US | disclosed |
| US-20160159800-A1 | MK2 INHIBITORS | N.V. ORGANON (NL) | 2016-06-09 | — | — | US | disclosed |
| US-9102676-B2 | MK2 inhibitors | MERCK SHARP & DOHME B.V. (NL) | 2015-08-11 | — | — | US | disclosed |
| US-9102676-B2 | MK2 inhibitors | MERCK SHARP & DOHME B.V. (NL) | 2015-08-11 | — | — | US | disclosed |
| US-20140288109-A1 | MK2 INHIBITORS | N.V. ORGANON (NL) | 2014-09-25 | — | — | US | disclosed |
| US-20140288109-A1 | MK2 INHIBITORS | N.V. ORGANON (NL) | 2014-09-25 | — | — | US | disclosed |
| US-8772286-B2 | MK2 inhibitors | MERCK SHARP & DOHME B.V. (NL) | 2014-07-08 | — | — | US | disclosed |
| US-8772286-B2 | MK2 inhibitors | MERCK SHARP & DOHME B.V. (NL) | 2014-07-08 | — | — | US | disclosed |
| EP-2513111-B1 | MK2 INHIBITORS | MERCK SHARP & DOHME (NL) | 2013-10-02 | — | — | EP | disclosed |
| EP-2513111-A1 | MK2 INHIBITORS | MSD Oss B.V. (NL) | 2012-10-24 | — | — | EP | disclosed |
| US-20120245175-A1 | MK2 INHIBITORS | N.V. ORGANON (NL) | 2012-09-27 | — | — | US | disclosed |
| US-20120245175-A1 | MK2 INHIBITORS | N.V. ORGANON (NL) | 2012-09-27 | — | — | US | disclosed |
| WO-2011073119-A1 | MK2 INHIBITORS | N.V. ORGANON (NL) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073119-A1 | MK2 INHIBITORS | N.V. ORGANON (NL) | 2011-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140288109-A1 | MK2 INHIBITORS | MKNK2, MAPKAPK2, MAP3K2 | HDAC1 141/4885HDAC8 479/4885HDAC6 152/4885 |
| US-20160159800-A1 | MK2 INHIBITORS | MKNK2, MAPKAPK2, MAP3K2 | HDAC1 179/4885HDAC8 602/4885HDAC6 187/4885 |
| US-20120245175-A1 | MK2 INHIBITORS | MKNK2, MAPKAPK2, MAP3K2 | HDAC1 141/4885HDAC8 479/4885HDAC6 152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.