Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 8/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.52 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.52 |
| ▸ | TTK | P33981 | 4/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.43 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1997257 | 0.82 | TTK (0.56) | MAP2K4MAPK1MAPK6MAPKAPK2TTK | |
| SCHEMBL5387981 | 0.78 | AURKA (0.66) | MAP2K4MAPK1MAPK6TTKHTR7 | |
| SCHEMBL5078605 | 0.75 | MAP2K4 (0.55) | MAP2K4MAPK1MAPK6MAPKAPK2TTK | |
| SCHEMBL30639606 | 0.74 | HTR7 (0.46) | MAP2K4HTR7IDO1HPGDPPARG | |
| SCHEMBL383361 | 0.73 | MAPK1 (0.47) | MAP2K4MAPK1MAPK6MAPKAPK2TTK | |
| SCHEMBL29768032 | 0.73 | MAPK1 (0.47) | MAP2K4MAPK1MAPK6MAPKAPK2TTK | |
| SCHEMBL17829602 | 0.70 | MAP2K4 (0.69) | MAP2K4MAPK1MAPK6MAPKAPK2MAPKAPK3 | |
| SCHEMBL3802281 | 0.69 | IMPDH2 (0.44) | MAP2K4MAPK1MAPK6MAPKAPK2TTK | |
| SCHEMBL8817864 | 0.69 | HTR7 (0.44) | MAP2K4TTKHTR7IDO1CSNK1D | |
| SCHEMBL13525180 | 0.68 | MAP2K4 (0.51) | MAP2K4MAPK1MAPK6MAPKAPK2MAPKAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180133221-A1 | ADMINISTRATION OF UBIQUITIN-ACTIVATING ENZYME INHIBITOR AND CHEMOTHERAPEUTIC AGENTS | MILLENNIUM PHARMACEUTICALS, INC. | 2018-05-17 | — | — | US | disclosed |
| US-20170333434-A1 | ADMINISTRATION OF UBIQUITIN-ACTIVATING ENZYME INHIBITOR AND RADIATION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170333434-A1 | ADMINISTRATION OF UBIQUITIN-ACTIVATING ENZYME INHIBITOR AND RADIATION | UBE2E1, UBA1, USP1 | MAP2K4 2113/4885MAPK1 2082/4885MAPK6 3398/4885 |
| US-20180133221-A1 | ADMINISTRATION OF UBIQUITIN-ACTIVATING ENZYME INHIBITOR AND CHEMOTHERAPEUTIC AGENTS | USP1, UBA1, UBE2E1 | MAP2K4 2062/4885MAPK1 2653/4885MAPK6 3447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.