Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.35 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11994355 | 0.86 | GCGR (0.41) | GCGRKIF11MAPK1MAP2K4MAPKAPK2 | |
| SCHEMBL18914333 | 0.83 | MRGPRX4 (0.36) | MRGPRX4KIF11S1PR1CYP1A2TSHR | |
| SCHEMBL29738108 | 0.83 | MRGPRX4 (0.36) | MRGPRX4KIF11S1PR1CYP1A2TSHR | |
| SCHEMBL16638758 | 0.81 | DPP4 (0.39) | MRGPRX4KIF11DPP4ADRB1CYP2D6 | |
| SCHEMBL19568082 | 0.79 | DPP4 (0.34) | MRGPRX4KIF11DPP4 | |
| SCHEMBL13185576 | 0.79 | TRPV4 (0.35) | MRGPRX4DPP4S1PR1ADRB1ADRA2A | |
| SCHEMBL20256735 | 0.79 | DPP4 (0.38) | MRGPRX4KIF11DPP4CYP2D6 | |
| SCHEMBL13160946 | 0.78 | GABRA1 (0.41) | DPP4CYP2D6 | |
| SCHEMBL6499247 | 0.77 | MAPK1 (0.35) | GCGRMAPK1MAP2K4MAPKAPK2MAPKAPK3 | |
| SCHEMBL19566851 | 0.76 | HRH4 (0.33) | GCGRDPP4ADRB1ADRA2AADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017201468-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2017-11-23 | — | — | WO | disclosed |