Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.35 |
| ▸ | SCN1A | P35498 | 2/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19634133 | 0.90 | HTR2A (0.38) | KDM4ESCN8ASCN1ANR1I2SCN1B | |
| SCHEMBL20256322 | 0.84 | SCN8A (0.51) | SCN8ASCN1ANR1I2SCN1BSCN5A | |
| SCHEMBL19634333 | 0.81 | SCN1A (0.33) | KDM4ESCN8ASCN1ANR1I2SCN1B | |
| SCHEMBL19634304 | 0.77 | ACLY (0.35) | SCN8ASCN1ANR1I2SCN1BSCN5A | |
| SCHEMBL19634257 | 0.75 | SCN8A (0.39) | SCN8ASCN1A | |
| SCHEMBL20256415 | 0.74 | HTR2A (0.38) | KDM4EHTR2ASLC6A4KCNH2APLNR | |
| SCHEMBL20256934 | 0.74 | CYP1A2 (0.38) | KDM4EHTR2ASLC6A4KCNH2TSHR | |
| SCHEMBL20256744 | 0.74 | GAA (0.38) | KDM4EHTR2ASLC6A4KCNH2TSHR | |
| SCHEMBL19633964 | 0.74 | MAPT (0.34) | KDM4ESCN8AMEN1KMT2AMAPT | |
| SCHEMBL20256930 | 0.73 | CYP1A2 (0.39) | KDM4ETSHRALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017201468-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2017-11-23 | — | — | WO | disclosed |