Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.33 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1233249 | 0.87 | MPO (0.49) | MPOLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9197577 | 0.82 | MMP2 (0.43) | MPONPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL20521730 | 0.81 | MPO (0.47) | MPOLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27762349 | 0.78 | BAZ2B (0.36) | MPOLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6778177 | 0.78 | MPO (0.47) | MPOLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19381360 | 0.77 | LMNA (0.36) | LMNANPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL3576265 | 0.76 | HCAR2 (0.42) | MAPTKDM4EGAABAZ2B | |
| SCHEMBL6079670 | 0.76 | BAZ2B (0.37) | MPOLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7697931 | 0.76 | MPO (0.48) | MPOLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1234463 | 0.76 | LMNA (0.44) | MPOLMNANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017198341-A1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2017-11-23 | — | — | WO | disclosed |