Sugi Predict

Sugi Predict / Compounds / SCHEMBL3576265

SCHEMBL3576265

SCHEMBL3576265

CCc1cc(C(=O)O)nn1C

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ HCAR2 Q8TDS4 4/20 0.42
▸ KDM4E B2RXH2 2/20 0.37
▸ GRN P28799 1/20 0.37
▸ SORT1 Q99523 1/20 0.37
▸ BAZ2B Q9UIF8 1/20 0.37
▸ ALDH1A1 P00352 3/20 0.36
▸ APOBEC3A P31941 2/20 0.35
▸ POLB P06746 1/20 0.35
▸ GAA P10253 1/20 0.35
▸ APOBEC3G Q9HC16 1/20 0.35
▸ BCL2 P10415 1/20 0.35
▸ MDM2 Q00987 1/20 0.35
▸ MCL1 Q07820 1/20 0.35
▸ HCAR3 P49019 2/20 0.34
▸ RPA1 P27694 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ HTT P42858 1/20 0.34
▸ MARS1 P56192 1/20 0.34
▸ P2RY14 Q15391 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6442036 0.89 HCAR2 (0.45) HCAR2KDM4EGRNSORT1BAZ2B
SCHEMBL8508062 0.85 HCAR2 (0.39) HCAR2KDM4EGRNSORT1BAZ2B
SCHEMBL6079670 0.85 BAZ2B (0.37) HCAR2BAZ2BALDH1A1MAPT
SCHEMBL8921837 0.84 HCAR2 (0.32) HCAR2BCL2MDM2MCL1
SCHEMBL1233408 0.83 PLA2G10 (0.45) KDM4EBAZ2BALDH1A1POLBMAPT
SCHEMBL27762349 0.83 BAZ2B (0.36) KDM4EBAZ2BALDH1A1POLBGAA
SCHEMBL730888 0.80 MDM2 (0.36) HCAR2KDM4EGRNSORT1BAZ2B
SCHEMBL19635568 0.80 BAZ2B (0.34) BAZ2B
SCHEMBL9197577 0.80 MMP2 (0.43) KDM4EBAZ2BALDH1A1POLBMAPT
SCHEMBL12985115 0.80 HCAR2 (0.47) HCAR2KDM4EGRNSORT1BAZ2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111108109-A Substituted dihydrothienopyrimidines and their use as phosphodiesterase inhibitors 利奥制药有限公司 2020-05-05 — — CN claimed
CN-101798316-B Triazolothiadiazole compounds and preparation method and application thereof NANKAI UNIVERSITY (CN) 2011-11-30 — — CN claimed
CN-101798316-A Triazolothiadiazole compounds and preparation method and application thereof UNIV NANKAI 2010-08-11 — — CN claimed
CN-100488962-C Derivative of thiadiazoles containing cyclo oxdiazole, synthetic method, and biological activity UNIV NANKAI (CN) 2009-05-20 — — CN claimed
WO-2025049827-A1 FRAGRANCE AND FLAVOR COMPOSITIONS COMPRISING PYRAZOLE DERIVATIVES OSMO LABS, PBC (US) 2025-03-06 — — WO disclosed
US-11891404-B2 Substituted macrocyclic indole derivatives BAYER AKTIENGESELLSCHAFT (DE) 2024-02-06 — — US disclosed
CN-111757884-B Substituted macrocyclic indole derivatives 拜耳股份公司 2023-12-19 — — CN disclosed
US-20230112244-A1 SUBSTITUTED MACROCYCLIC INDOLE DERIVATIVES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2023-04-13 — — US disclosed
US-11440923-B2 Substituted macrocyclic indole derivatives BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2022-09-13 — — US disclosed
CN-111757884-A Substituted macrocyclic indole derivatives 拜耳股份公司 2020-10-09 — — CN disclosed
EP-3710451-A1 SUBSTITUTED MACROCYCLIC INDOLE DERIVATIVES Bayer Aktiengesellschaft (DE) 2020-09-23 — — EP disclosed
CN-111108109-A Substituted dihydrothienopyrimidines and their use as phosphodiesterase inhibitors 利奥制药有限公司 2020-05-05 — — CN disclosed
US-20070032478-A1 Kinase Inhibitors ALLERGAN, INC. 2007-02-08 — — US disclosed
WO-2007008895-A1 KINASE INHIBITORS ALLERGAN, INC. (US) 2007-01-18 — — WO disclosed
US-7045619-B2 2-(pyrazol-3-yl)carbapenem derivatives SMITHKLINE BEECHAM P.L.C. (GB) 2006-05-16 — — US disclosed
US-20030166923-A1 2-(pyrazol-3-yl)carbapenem derivatives SMITHKLINE BEECHAM P.L.C. 2003-09-04 — — US disclosed
EP-0725783-B1 2-(PYRAZOL-3-YL)CARBAPENEM DERIVATIVES SMITHKLINE BEECHAM PLC (GB) 2002-12-18 — — EP disclosed
US-20020147333-A1 2-(pyrazol-3-yl)carbapenem derivatives SMITHKLINE BEECHAM P.L.C. 2002-10-10 — — US disclosed
US-5612477-A 2-(pyrazol-3-yl)carbapenem derivatives SMITHKLINE BEECHAM P.L.C 1997-03-18 — — US disclosed
US-5606051-A 2-(pyrazol-3-yl)carbapenem derivatives SMITHKLINE BEECHAM P.L.C. (GB) 1997-02-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230112244-A1 SUBSTITUTED MACROCYCLIC INDOLE DERIVATIVES FOXM1, CCND2, CCNI HCAR2 758/4885KDM4E 1649/4885GRN 879/4885
US-11891404-B2 Substituted macrocyclic indole derivatives FOXM1, CCND2, CCNI HCAR2 758/4885KDM4E 1649/4885GRN 879/4885
US-20020147333-A1 2-(pyrazol-3-yl)carbapenem derivatives DPEP1, DHPS, JMJD6 HCAR2 297/4885KDM4E 154/4885GRN 4865/4885
US-20030166923-A1 2-(pyrazol-3-yl)carbapenem derivatives DHPS, DPEP1, JMJD6 HCAR2 304/4885KDM4E 149/4885GRN 4854/4885
US-11440923-B2 Substituted macrocyclic indole derivatives FOXM1, CCND2, CCNI HCAR2 758/4885KDM4E 1649/4885GRN 879/4885
US-20070032478-A1 Kinase Inhibitors ABL1, LCK, ERBB2 HCAR2 2531/4885KDM4E 1393/4885GRN 4010/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.