Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25021680 | 0.95 | CRHR1 (0.35) | HRH3TLR7CRHR1 | |
| SCHEMBL21912197 | 0.78 | HPGD (0.32) | HRH3TLR7 | |
| SCHEMBL21895740 | 0.77 | ALDH1A1 (0.41) | HRH3TLR7CRHR1 | |
| SCHEMBL21912198 | 0.72 | CRHR1 (0.34) | CRHR1 | |
| SCHEMBL19636917 | 0.72 | HRH3 (0.42) | HRH3 | |
| SCHEMBL22087281 | 0.69 | KRAS (0.40) | HRH3TLR7 | |
| SCHEMBL21895536 | 0.67 | TLR7 (0.38) | TLR7 | |
| SCHEMBL21912124 | 0.65 | — | — | |
| SCHEMBL19637165 | 0.62 | HRH3 (0.45) | HRH3TLR7 | |
| SCHEMBL22994702 | 0.61 | ALDH1A1 (0.41) | HRH3TLR7CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020055760-A1 | COMBINATION THERAPIES | Mirati Therapeutics, Inc. (US) | 2020-03-19 | — | — | WO | disclosed |