Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 5/20 | 0.43 |
| ▸ | TEAD3 | Q99594 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.36 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22994789 | 0.91 | KRAS (0.44) | KRASTEAD3HRH3JAK3TLR7 | |
| SCHEMBL21896284 | 0.87 | KRAS (0.40) | KRASJAK3BTK | |
| SCHEMBL22087281 | 0.86 | KRAS (0.40) | KRASTEAD3HRH3JAK3TLR9 | |
| SCHEMBL21895629 | 0.86 | KRAS (0.38) | KRASTEAD3HRH3JAK3BTK | |
| SCHEMBL22994733 | 0.85 | JAK3 (0.40) | KRASTEAD3JAK3BTK | |
| SCHEMBL22994767 | 0.83 | BTK (0.44) | KRASJAK3BTK | |
| SCHEMBL21895574 | 0.80 | KRAS (0.39) | KRASJAK3BTK | |
| SCHEMBL22994731 | 0.77 | NUDT1 (0.38) | KRASJAK3BTK | |
| SCHEMBL21846179 | 0.77 | TEAD3 (0.37) | KRASTEAD3JAK3BTK | |
| SCHEMBL19959230 | 0.73 | KRAS (0.61) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020055756-A1 | COMBINATION THERAPIES | Mirati Therapeutics, Inc. (US) | 2020-03-19 | — | — | WO | disclosed |