Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | BACE1 | P56817 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.31 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19643071 | 0.76 | UTS2R (0.41) | UTS2RKDM4ESMN1; SMN2ALDH1A1HTT | |
| SCHEMBL19642808 | 0.75 | UTS2R (0.39) | UTS2RKDM4ESMN1; SMN2ALDH1A1HTT | |
| SCHEMBL19640210 | 0.74 | NPC1 (0.40) | UTS2RKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL19640185 | 0.73 | KDM4E (0.41) | UTS2RKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL19640199 | 0.69 | UTS2R (0.39) | UTS2RKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL19663376 | 0.68 | L3MBTL1 (0.39) | UTS2RKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL19640213 | 0.68 | UTS2R (0.35) | UTS2RKDM4ESMN1; SMN2ALDH1A1HTT | |
| SCHEMBL19640193 | 0.68 | KDM4E (0.35) | UTS2RKDM4ESMN1; SMN2ALDH1A1HTT | |
| SCHEMBL19640186 | 0.68 | L3MBTL1 (0.44) | KDM4ESMN1; SMN2ALDH1A1HPGDLMNA | |
| SCHEMBL21331685 | 0.67 | KDM4E (0.43) | KDM4ESMN1; SMN2ALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10100052-B2 | — | — | 2018-10-16 | — | — | US | disclosed |
| US-20170342068-A1 | COMPOUNDS FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION | GILEAD SCIENCES, INC. | 2017-11-30 | — | — | US | disclosed |
| WO-2017205115-A1 | COMPOUNDS FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION | GILEAD SCIENCES, INC. (US) | 2017-11-30 | — | — | WO | disclosed |
| US-20170342068-A1 | COMPOUNDS FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION | GILEAD SCIENCES, INC. | 2017-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10100052-B2 | — | HAVCR2, PYGL, FABP1 | UTS2R 3336/4885KDM4E 4413/4885SMN1; SMN2 2109/4885 |
| US-20170342068-A1 | COMPOUNDS FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION | HAVCR2, PYGL, OAT | UTS2R 3013/4885KDM4E 4217/4885SMN1; SMN2 3163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.