Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1965300 | 0.91 | P2RX7 (0.42) | KMT2AMEN1P2RX7L3MBTL1MAPT | |
| SCHEMBL1963992 | 0.85 | KDM4E (0.45) | KMT2AMEN1P2RX7MAPTSMN1; SMN2 | |
| SCHEMBL1965654 | 0.83 | EGLN1 (0.51) | KMT2AMEN1L3MBTL1TP53 | |
| SCHEMBL1967018 | 0.82 | L3MBTL1 (0.44) | KMT2AMEN1L3MBTL1POLBALDH1A1 | |
| SCHEMBL3723620 | 0.79 | KMT2A (0.43) | KMT2AMEN1P2RX7L3MBTL1MAPT | |
| SCHEMBL1967638 | 0.78 | MEN1 (0.41) | KMT2AMEN1L3MBTL1POLBMAPT | |
| SCHEMBL1964633 | 0.74 | MAPT (0.40) | KMT2AMEN1L3MBTL1MAPTNPSR1 | |
| SCHEMBL7453380 | 0.73 | L3MBTL1 (0.50) | KMT2AMEN1L3MBTL1POLBMAPT | |
| SCHEMBL1967789 | 0.72 | EGLN1 (0.44) | KMT2AMEN1L3MBTL1 | |
| SCHEMBL1967331 | 0.72 | HSP90AA1 (0.41) | KMT2AMEN1L3MBTL1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334682-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | Fibrogen, Inc. (US) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010022240-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | FIBROGEN, INC. (US) | 2010-02-25 | — | — | WO | disclosed |