Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | PRKACG | P22612 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1964132 | 0.85 | KMT2A (0.45) | KDM4ESMN1; SMN2P2RX7MAPTALDH1A1 | |
| SCHEMBL1968792 | 0.85 | EGLN1 (0.40) | KDM4EHDAC1HDAC8HDAC6EGLN2 | |
| SCHEMBL1969288 | 0.84 | EGLN1 (0.53) | HDAC1HDAC8HDAC6EGLN2EGLN1 | |
| SCHEMBL1965300 | 0.84 | P2RX7 (0.42) | KDM4ESMN1; SMN2HDAC1HDAC8HDAC6 | |
| SCHEMBL3725348 | 0.81 | KDM4E (0.40) | KDM4ESMN1; SMN2HDAC1HDAC8HDAC6 | |
| SCHEMBL1967018 | 0.71 | L3MBTL1 (0.44) | KDM4EEGLN1ALDH1A1MEN1KMT2A | |
| SCHEMBL3732846 | 0.70 | EGLN1 (0.38) | KDM4ESMN1; SMN2HDAC1HDAC8HDAC6 | |
| SCHEMBL3732845 | 0.70 | EGLN1 (0.38) | KDM4ESMN1; SMN2HDAC1HDAC8HDAC6 | |
| SCHEMBL1964633 | 0.70 | MAPT (0.40) | KDM4ESMN1; SMN2MAPTALDH1A1MEN1 | |
| SCHEMBL3730753 | 0.70 | EGLN1 (0.53) | EGLN2EGLN1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334682-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | Fibrogen, Inc. (US) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010022240-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | FIBROGEN, INC. (US) | 2010-02-25 | — | — | WO | disclosed |