Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.40 |
| ▸ | CNR1 | P21554 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1968792 | 0.88 | EGLN1 (0.40) | EGLN1CNR1KDM4EALDH1A1CNR2 | |
| SCHEMBL1965654 | 0.84 | EGLN1 (0.51) | L3MBTL1MEN1KMT2AEGLN1TP53 | |
| SCHEMBL1964132 | 0.82 | KMT2A (0.45) | L3MBTL1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL1966135 | 0.81 | L3MBTL1 (0.44) | L3MBTL1MEN1KMT2AEGLN1CNR1 | |
| SCHEMBL1966134 | 0.81 | L3MBTL1 (0.44) | L3MBTL1MEN1KMT2AEGLN1CNR1 | |
| SCHEMBL1967789 | 0.76 | EGLN1 (0.44) | L3MBTL1MEN1KMT2AEGLN1 | |
| SCHEMBL1968417 | 0.75 | EGLN3 (0.44) | EGLN1 | |
| SCHEMBL1967638 | 0.74 | MEN1 (0.41) | L3MBTL1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL3732845 | 0.73 | EGLN1 (0.38) | L3MBTL1EGLN1KDM4EALDH1A1CNR2 | |
| SCHEMBL3732846 | 0.73 | EGLN1 (0.38) | L3MBTL1EGLN1KDM4EALDH1A1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334682-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | Fibrogen, Inc. (US) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010022240-A1 | PYRROLO [ 1, 2 -B] PYRIDAZINE DERIVATIVES AND THEIR USE AS HIF MODULATORS | FIBROGEN, INC. (US) | 2010-02-25 | — | — | WO | disclosed |