Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNASEL | Q05823 | 2/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.32 |
| ▸ | P2RX1 | P51575 | 3/20 | 0.32 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.32 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.32 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.31 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.31 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.31 |
| ▸ | POLRMT | O00411 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19644577 | 0.92 | RNASEL (0.31) | RNASELP2RX3P2RX1P2RX4 | |
| SCHEMBL19644575 | 0.80 | HIF1A (0.32) | — | |
| SCHEMBL17453498 | 0.77 | P2RY2 (0.41) | RNASELP2RX3P2RX1P2RX2P2RY2 | |
| SCHEMBL19644600 | 0.77 | POLRMT (0.36) | RNASELP2RX3P2RX1P2RX4POLRMT | |
| SCHEMBL17453495 | 0.76 | P2RY2 (0.38) | RNASELP2RX3P2RX1P2RX2P2RX4 | |
| SCHEMBL19644566 | 0.75 | POLRMT (0.36) | RNASELP2RX3P2RX1P2RX4POLRMT | |
| SCHEMBL19644602 | 0.73 | P2RY1 (0.40) | RNASELP2RX3P2RX1P2RX2P2RX4 | |
| SCHEMBL21880479 | 0.72 | POLRMT (0.35) | RNASELP2RX3P2RX1P2RX4P2RY2 | |
| SCHEMBL19644568 | 0.72 | P2RY1 (0.41) | RNASELP2RX3P2RX1P2RX2P2RX4 | |
| SCHEMBL31539949 | 0.71 | P2RX1 (0.44) | RNASELP2RX3P2RX1P2RX2P2RX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10179794-B2 | Thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-D]pyrimidines useful for treating respiratory syncitial virus infections | GILEAD SCIENCES, INC. (US) | 2019-01-15 | — | — | US | disclosed |
| US-20180072755-A1 | THIENO[3,2-d]PYRIMIDINE, FURO[3,2-d]PYRIMIDINE, AND PYRROLO[3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | GILEAD SCIENCES, INC. | 2018-03-15 | — | — | US | disclosed |
| US-9828388-B2 | Thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-D]pyrimidines useful for treating respiratory syncitial virus infections | GILEAD SCIENCES, INC. (US) | 2017-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10179794-B2 | Thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-D]pyrimidines useful for treating respiratory syncitial virus infections | DPYD, TYMS, TYMP | RNASEL 587/4885P2RX3 52/4885P2RX1 68/4885 |
| US-20180072755-A1 | THIENO[3,2-d]PYRIMIDINE, FURO[3,2-d]PYRIMIDINE, AND PYRROLO[3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | DPYD, TYMS, TYMP | RNASEL 587/4885P2RX3 52/4885P2RX1 68/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.