Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 3/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | RARG | P13631 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1966409 | 0.92 | LCK (0.42) | LCKHSD17B10THRBHTTRXRA | |
| SCHEMBL1973510 | 0.87 | HSD17B10 (0.44) | LCKHSD17B10THRBHTTRXRA | |
| SCHEMBL1970564 | 0.83 | LCK (0.41) | LCKHSD17B10THRBHTTSMN1; SMN2 | |
| SCHEMBL1965510 | 0.82 | HSD17B10 (0.42) | LCKHSD17B10THRBHTTSMN1; SMN2 | |
| SCHEMBL1967011 | 0.82 | LCK (0.45) | LCKHSD17B10THRBHTTRXRA | |
| SCHEMBL1964624 | 0.82 | LCK (0.45) | LCKHSD17B10THRBRORCCSNK2A2 | |
| SCHEMBL1967727 | 0.82 | LCK (0.56) | LCKHSD17B10THRBHTTSMN1; SMN2 | |
| SCHEMBL1964805 | 0.81 | KIF11 (0.41) | LCKHSD17B10RXRARORCCSNK2A2 | |
| SCHEMBL1967636 | 0.81 | LCK (0.46) | LCKHSD17B10THRBHTTSMN1; SMN2 | |
| SCHEMBL1967758 | 0.80 | LCK (0.45) | LCKHSD17B10THRBHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334652-A1 | 1H-BENZ IMIDAZOLE-5-CARBOXAMIDES AS ANTI-INFLAMMATORY AGENTS | Boehringer Ingelheim International GmbH (DE) | 2011-06-22 | — | — | EP | claimed |
| EP-2334652-A1 | 1H-BENZ IMIDAZOLE-5-CARBOXAMIDES AS ANTI-INFLAMMATORY AGENTS | Boehringer Ingelheim International GmbH (DE) | 2011-06-22 | — | — | EP | disclosed |