Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 7/20 | 0.57 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19658393 | 0.88 | NPY5R (0.53) | NPY5RNOTUMGPR119FFAR4ADRB1 | |
| SCHEMBL19652215 | 0.86 | NOTUM (0.57) | NPY5RNOTUMCCR5 | |
| SCHEMBL19658391 | 0.85 | NPY5R (0.60) | NPY5RNOTUMGPR119FFAR4ADRB1 | |
| SCHEMBL19710726 | 0.84 | NPY5R (0.62) | NPY5RNOTUMGPR119FFAR4ACACB | |
| SCHEMBL19652206 | 0.84 | GPR119 (0.44) | NPY5RGPR119ADRB1MEN1ALDH1A1 | |
| SCHEMBL19652140 | 0.79 | DRD2 (0.54) | MEN1ALDH1A1KMT2ACCR5 | |
| SCHEMBL17754015 | 0.79 | ADRB1 (0.56) | NPY5RNOTUMGPR119FFAR4ADRB1 | |
| SCHEMBL19710460 | 0.78 | NOTUM (0.60) | NPY5RNOTUMGPR119FFAR4ADRB1 | |
| SCHEMBL19711237 | 0.77 | CCR5 (0.53) | NPY5RNOTUMGPR119FFAR4ALDH1A1 | |
| SCHEMBL19710519 | 0.77 | PIK3CD (0.53) | NPY5RNOTUMGPR119FFAR4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | BRD4, BRDT, BRD3 | NPY5R 1431/4885NOTUM 2215/4885GPR119 988/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.