Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 9/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | CD44 | P16070 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | TGM2 | P21980 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL177194 | 0.78 | DRD2 (0.59) | PNMTADRA2AADRA2BADRA2CDRD2 | |
| SCHEMBL3141361 | 0.77 | PNMT (0.56) | PNMTADRA2AADRA2BADRA2CDRD2 | |
| SCHEMBL27380716 | 0.77 | HTR5A (0.39) | PNMTDRD2DRD4KDM4EMAPT | |
| SCHEMBL2062448 | 0.77 | HTR2A (0.38) | PNMTADRA2AADRA2BADRA2CDRD2 | |
| SCHEMBL3136478 | 0.77 | PNMT (0.56) | PNMTADRA2AADRA2BADRA2CDRD2 | |
| SCHEMBL30895914 | 0.77 | HTR5A (0.39) | PNMTDRD2DRD4KDM4EMAPT | |
| SCHEMBL19657741 | 0.77 | GAA (0.41) | PNMTDRD2DRD4KDM4EMAPT | |
| SCHEMBL21760178 | 0.74 | KDM4E (0.48) | PNMTADRA2AADRA2BADRA2CDRD2 | |
| SCHEMBL566283 | 0.74 | MAPT (0.54) | PNMTADRA2AADRA2BADRA2CDRD2 | |
| SCHEMBL21023869 | 0.73 | GAA (0.35) | ADRA2AADRA2BADRA2CDRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205536-A2 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |