Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 8/20 | 0.46 |
| ▸ | HTR2C | P28335 | 8/20 | 0.46 |
| ▸ | HTR2B | P41595 | 4/20 | 0.46 |
| ▸ | AHR | P35869 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR5A | P47898 | 3/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | HTR1D | P28221 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | HTR3A | P46098 | 2/20 | 0.39 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | F3 | P13726 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618092 | 0.85 | PNMT (0.56) | PNMTHTR2AHTR2CHTR2BAHR | |
| SCHEMBL154428 | 0.78 | DRD4 (0.64) | PNMTHTR2AHTR2CHTR2BAHR | |
| SCHEMBL3141361 | 0.77 | PNMT (0.56) | PNMTHTR2AHTR2CHTR2BAHR | |
| SCHEMBL27380716 | 0.77 | HTR5A (0.39) | PNMTHTR2AHTR2CHTR2BAHR | |
| SCHEMBL19657741 | 0.77 | GAA (0.41) | PNMTDRD4DRD2HTR5APARP1 | |
| SCHEMBL19657606 | 0.77 | PNMT (0.56) | PNMTDRD4DRD2ADRA2AADRA2B | |
| SCHEMBL30895914 | 0.77 | HTR5A (0.39) | PNMTHTR2AHTR2CHTR2BAHR | |
| SCHEMBL2062448 | 0.77 | HTR2A (0.38) | PNMTHTR2AHTR2CHTR2BDRD4 | |
| Bromide SCHEMBL949153 | 0.76 | DRD4 (0.62) | PNMTHTR2AHTR2CHTR2BAHR | |
| SCHEMBL8089058 | 0.74 | KDM4E (0.48) | PNMTHTR2AHTR2CHTR2BAHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11572374-B2 | N-cyano-7-azanorbornane derivatives and uses thereof | AMGEN INC. (US) | 2023-02-07 | — | — | US | disclosed |
| CN-1955179-B | [1,4]diazepino[6,7,1-IJ]quinoline derivatives as antipsychotic and antiobesity agents | WYETH CORP | 2010-07-14 | — | — | CN | disclosed |
| US-7687620-B2 | [1,4]diazepino[6,7,1-IJ]quinoline derivatives as antipsychotic and antiobesity agents | WYETH LLC (US) | 2010-03-30 | — | — | US | disclosed |
| EP-1497293-B1 | (1,4)DIAZEPINO(6,7,1-IJ)QUINOLINE DERIVATIVES AS ANTI PSYCHOTIC AND ANTIOBESITY AGENTS | WYETH CORP (US) | 2008-06-11 | — | — | EP | disclosed |
| US-20070004707-A1 | [1,4]Diazepino[6,7,1-IJ]quinoline derivatives as antipsychotic and antiobesity agents | RAMAMOORTHY P S | 2007-01-04 | — | — | US | disclosed |
| US-7129237-B2 | [1,4]Diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | WYETH (US) | 2006-10-31 | — | — | US | disclosed |
| CN-1662533-A | [1,4] diazepino [6,7, 1-IJ ] quinoline derivatives as antipsychotic and antiobesity agents | WYETH CORP (US) | 2005-08-31 | — | — | CN | disclosed |
| EP-1497293-A1 | (1,4)DIAZEPINO(6,7,1-IJ)QUINOLINE DERIVATIVES AS ANTI PSYCHOTIC AND ANTIOBESITY AGENTS | Wyeth (US) | 2005-01-19 | — | — | EP | disclosed |
| US-20040009970-A1 | [1,4]Diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | WYETH | 2004-01-15 | — | — | US | disclosed |
| WO-2003091250-A1 | [1,4]DIAZEPINO[6,7,1-IJ]QUINOLINE DERIVATIVES AS ANTI PSYCHOTIC AND ANTIOBESITY AGENTS | WYETH (US) | 2003-11-06 | — | — | WO | disclosed |
| US-6503900-B2 | For treatment or prevention of disorders such as obsessive-compulsive disorder, depression, anxiety, schizophrenia | WYETH | 2003-01-07 | — | — | US | disclosed |
| US-20020086860-A1 | [1,4]Diazepino [6,7,1-jk] carbazoles and derivatives | AMERICAN HOME PRODUCTS CORPORATION | 2002-07-04 | — | — | US | disclosed |
| WO-2002036596-A2 | CYCLOALKYL[b][1,4]DIAZEPINO[6,7,1-hi]INDOLES AND DERIVATIVES | WYETH (US) | 2002-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020086860-A1 | [1,4]Diazepino [6,7,1-jk] carbazoles and derivatives | GRIK1, GRIK3, GRIK4 | PNMT 1293/4885HTR2A 169/4885HTR2C 31/4885 |
| US-20070004707-A1 | [1,4]Diazepino[6,7,1-IJ]quinoline derivatives as antipsychotic and antiobesity agents | HTR2C, HTR1A, HTR1D | PNMT 445/4885HTR2A 7/4885HTR2C 1/4885 |
| US-11572374-B2 | N-cyano-7-azanorbornane derivatives and uses thereof | CYP3A7, CYP51A1, NT5C3B | PNMT 1830/4885HTR2A 4645/4885HTR2C 4091/4885 |
| US-20040009970-A1 | [1,4]Diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | HTR2C, HTR1A, HTR1D | PNMT 494/4885HTR2A 6/4885HTR2C 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.