Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 14/20 | 0.66 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.62 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.62 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.62 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.62 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.62 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.62 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.62 |
| ▸ | DRD2 | P14416 | 1/20 | 0.62 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.62 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.62 |
| ▸ | MAOA | P21397 | 1/20 | 0.62 |
| ▸ | DRD4 | P21917 | 1/20 | 0.62 |
| ▸ | MAOB | P27338 | 1/20 | 0.62 |
| ▸ | HRH1 | P35367 | 1/20 | 0.62 |
| ▸ | DRD3 | P35462 | 1/20 | 0.62 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.62 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19658483 | 0.86 | CCR5 (0.55) | OPRM1OPRD1OPRK1ADRA1AADRA1B | |
| SCHEMBL13478892 | 0.86 | OPRM1 (0.64) | OPRM1OPRD1OPRK1ADRA1AADRA1B | |
| SCHEMBL9030647 | 0.86 | SIGMAR1 (0.67) | OPRM1DRD2CHRM3KCNH2SIGMAR1 | |
| SCHEMBL7496079 | 0.85 | OPRM1 (0.64) | OPRM1OPRD1OPRK1ADRA1AADRA1B | |
| SCHEMBL684578 | 0.84 | OPRM1 (0.77) | OPRM1OPRD1OPRK1ADRA1AADRA1B | |
| SCHEMBL11015643 | 0.82 | OPRM1 (0.61) | OPRM1OPRD1OPRK1ADRA1AADRA1B | |
| SCHEMBL19658478 | 0.82 | CCR5 (0.58) | OPRM1OPRD1OPRK1 | |
| SCHEMBL10843469 | 0.81 | OPRM1 (0.60) | OPRM1OPRD1OPRK1ADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL10656003 | 0.81 | OPRM1 (0.60) | OPRM1OPRD1OPRK1ADRA1AADRA1B | |
| SCHEMBL10654998 | 0.81 | LTA4H (0.64) | OPRM1DRD2CHRM3KCNH2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | BRD4, BRDT, BRD3 | OPRM1 4350/4885OPRD1 3596/4885OPRK1 2987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.