Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.57 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 7/20 | 0.38 |
| ▸ | JAK1 | P23458 | 3/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2730240 | 0.81 | NUDT1 (0.62) | MAP3K5NUDT1FYNJAK1EGLN2 | |
| SCHEMBL2772772 | 0.80 | NUDT1 (0.65) | MAP3K5NUDT1FYNJAK1EGLN2 | |
| SCHEMBL19659256 | 0.77 | EGLN2 (0.56) | MAP3K5NUDT1FYNJAK1EGLN2 | |
| SCHEMBL18366702 | 0.77 | MAP3K5 (0.55) | MAP3K5NUDT1FYNJAK1EGLN2 | |
| SCHEMBL18154780 | 0.75 | JAK1 (0.44) | NUDT1JAK1EGLN2JAK2 | |
| SCHEMBL19658699 | 0.74 | GRM2 (0.44) | NUDT1FYNJAK1 | |
| SCHEMBL2788079 | 0.74 | MAP3K5 (0.85) | MAP3K5JAK1EGLN2JAK2 | |
| Cyclopropane SCHEMBL16986945 | 0.74 | MAP3K5 (0.73) | MAP3K5JAK1EGLN2JAK2 | |
| SCHEMBL19658700 | 0.73 | NUDT1 (0.38) | NUDT1JAK1EGLN2JAK2 | |
| SCHEMBL2772932 | 0.73 | MAP3K5 (1.00) | MAP3K5JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017004500-A9 | BICYCLIC LACTAMS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |