Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 4/20 | 0.35 |
| ▸ | PARP1 | P09874 | 7/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.35 |
| ▸ | PARP3 | Q9Y6F1 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18367852 | 0.82 | JAK2 (0.41) | JAK2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL22888304 | 0.82 | RIPK1 (0.40) | L3MBTL1JAK2ALDH1A1 | |
| SCHEMBL22439076 | 0.80 | KDM4E (0.43) | L3MBTL1NUDT1PARP1MAPK1KDM4E | |
| SCHEMBL19658956 | 0.76 | PARP1 (0.39) | L3MBTL1NUDT1JAK2PARP1PARP2 | |
| SCHEMBL18366710 | 0.76 | NUDT1 (0.56) | L3MBTL1NUDT1MAPK1KDM4EALDH1A1 | |
| SCHEMBL24370916 | 0.74 | HAVCR2 (0.38) | NUDT1JAK2 | |
| SCHEMBL19659614 | 0.73 | KDM4E (0.43) | L3MBTL1PARP1MAPK1KDM4EALDH1A1 | |
| SCHEMBL24996360 | 0.70 | NUDT1 (0.32) | NUDT1 | |
| SCHEMBL19659253 | 0.70 | EGLN2 (0.50) | NUDT1JAK2PARP1 | |
| SCHEMBL22887918 | 0.69 | NUDT1 (0.33) | NUDT1JAK2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3760625-B1 | BICYCLIC LACTAMS AS RECEPTOR-INTERACTING PROTEIN-1 (RIP1) KINASE INHIBITORS FOR TREATING E.G. INFLAMMATORY DISEASES | HOFFMANN LA ROCHE (CH) | 2024-03-27 | — | — | EP | claimed |
| EP-3760625-A1 | BICYCLIC LACTAMS AS RECEPTOR-INTERACTING PROTEIN-1 (RIP1) KINASE INHIBITORS FOR TREATING E.G. INFLAMMATORY DISEASES | F. Hoffmann-La Roche AG (CH) | 2021-01-06 | — | — | EP | disclosed |
| WO-2017004500-A9 | BICYCLIC LACTAMS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |