Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25551291 | 0.87 | TGM2 (0.36) | CYP19A1 | |
| SCHEMBL15964573 | 0.84 | BLM (0.32) | CYP19A1TSHR | |
| SCHEMBL22887844 | 0.82 | RIPK1 (0.31) | — | |
| SCHEMBL15964739 | 0.73 | MMP12 (0.33) | TSHRHTR7HTR2BTMEM97SIGMAR1 | |
| SCHEMBL17321201 | 0.72 | GAA (0.49) | — | |
| SCHEMBL23188854 | 0.69 | ALDH1A1 (0.38) | CYP19A1TSHRHTR7HTR2BTMEM97 | |
| SCHEMBL15964641 | 0.69 | TGM2 (0.36) | CYP19A1TSHR | |
| SCHEMBL28719592 | 0.69 | TGM2 (0.36) | CYP19A1TSHR | |
| SCHEMBL30587582 | 0.69 | TGM2 (0.36) | CYP19A1TSHR | |
| SCHEMBL19659466 | 0.69 | RIPK1 (0.34) | CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017004500-A9 | BICYCLIC LACTAMS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |