Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | GSR | P00390 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.34 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.34 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15873926 | 0.81 | KDM4E (0.42) | PTGS2NPC1ALDH1A1POLBRAB9A | |
| SCHEMBL27752586 | 0.75 | TDO2 (0.39) | ALDH1A1CYP2A6TDO2 | |
| SCHEMBL27773472 | 0.73 | ALDH1A1 (0.38) | MEN1KMT2ANPC1ALDH1A1POLB | |
| SCHEMBL27773454 | 0.72 | DPP4 (0.40) | MEN1KMT2ANPC1ALDH1A1RAB9A | |
| SCHEMBL1797330 | 0.71 | PTGS2 (0.67) | PTGS2HSP90AA1MEN1KMT2AGPR55 | |
| SCHEMBL6630764 | 0.69 | HSP90AA1 (0.46) | PTGS2HSP90AA1NPC1ALDH1A1RAB9A | |
| SCHEMBL6630766 | 0.69 | PTGS2 (0.47) | PTGS2HSP90AA1MEN1KMT2ANPC1 | |
| SCHEMBL2797055 | 0.69 | LMNA (0.59) | PTGS2HSP90AA1NPC1ALDH1A1RAB9A | |
| SCHEMBL2886350 | 0.69 | HSP90AA1 (0.54) | PTGS2HSP90AA1MEN1KMT2ANPC1 | |
| SCHEMBL5729643 | 0.69 | HSP90AA1 (0.46) | PTGS2HSP90AA1MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334636-A2 | HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | Pfizer Inc. (US) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010032147-A2 | HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | PFIZER INC. (US) | 2010-03-25 | — | — | WO | disclosed |
| CN-1135210-C | Process for preparation of 1-aryl-3-cyclopropyl-1,3-propanediones | ����-���ʿ�ũҵ��˾ | 2004-01-21 | — | — | CN | disclosed |
| CN-1262670-A | Preparation method of 1-aryl-3-cyclopropyl-1, 3-propanedione | RHONE POULENC AGROCHIMIE (FR) | 2000-08-09 | — | — | CN | disclosed |