Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.64 |
| ▸ | RAB9A | P51151 | 5/20 | 0.64 |
| ▸ | MAOB | P27338 | 3/20 | 0.64 |
| ▸ | MAOA | P21397 | 2/20 | 0.64 |
| ▸ | ACHE | P22303 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | KCNK3 | O14649 | 6/20 | 0.58 |
| ▸ | KCNK9 | Q9NPC2 | 5/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19662769 | 0.90 | KMT2A (0.61) | NPC1RAB9AMAOBMAOAACHE | |
| SCHEMBL29510910 | 0.87 | NPC1 (0.78) | NPC1RAB9AMAOBMAOAACHE | |
| SCHEMBL24367775 | 0.85 | MAOB (0.64) | NPC1RAB9AMAOBMAOAACHE | |
| SCHEMBL21237220 | 0.85 | MAOB (0.60) | NPC1RAB9AMAOBMAOAACHE | |
| SCHEMBL16686040 | 0.80 | NPC1 (0.63) | NPC1RAB9AMAOBMAOAACHE | |
| SCHEMBL15875716 | 0.78 | MAOB (1.00) | NPC1RAB9AMAOBMAOAACHE | |
| SCHEMBL15874997 | 0.78 | MAOB (1.00) | NPC1RAB9AMAOBMAOAACHE | |
| SCHEMBL19662795 | 0.77 | MAOB (0.54) | NPC1RAB9AMAOBMAOAACHE | |
| SCHEMBL1167819 | 0.76 | F2 (0.50) | NPC1RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL19662804 | 0.76 | KDM1A (0.65) | NPC1RAB9AKMT2AMEN1KCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464286-B1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH INC (US) | 2021-08-18 | — | — | EP | disclosed |
| WO-2017205538-A1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |