Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.54 |
| ▸ | MAOA | P21397 | 3/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | HTR1F | P30939 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MLLT1 | Q03111 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19662769 | 0.87 | KMT2A (0.61) | MAOBMAOAACHENPC1RAB9A | |
| SCHEMBL21237216 | 0.84 | HDAC8 (0.55) | MAOBMAOAACHENPC1RAB9A | |
| SCHEMBL19662760 | 0.77 | NPC1 (0.64) | MAOBMAOAACHENPC1RAB9A | |
| SCHEMBL30006626 | 0.76 | MAPT (0.53) | MAOBMAOAACHENPC1RAB9A | |
| SCHEMBL4898390 | 0.76 | TRPV1 (0.52) | MAOBMAOAACHENPC1RAB9A | |
| SCHEMBL29510910 | 0.76 | NPC1 (0.78) | MAOBMAOAACHENPC1RAB9A | |
| SCHEMBL19662799 | 0.76 | KDM1A (0.63) | MAOANPC1RAB9AALDH1A1GRM5 | |
| SCHEMBL30323212 | 0.76 | GRM4 (0.54) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL20524569 | 0.76 | GRM4 (0.54) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL24367775 | 0.74 | MAOB (0.64) | MAOBMAOAACHENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464286-B1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH INC (US) | 2021-08-18 | — | — | EP | disclosed |
| WO-2017205538-A1 | PYRAZOLOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2017-11-30 | — | — | WO | disclosed |